Is There Any Correlation Between The Elevated Plasma Levels and Gene Variations of Factor VIII in Turkish Thrombosis Patients?

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dc.authoridAY, Mustafa/0000-0002-1765-4858
dc.contributor.authorAy, Mustafa
dc.contributor.authorDolek, Bilgen
dc.contributor.authorErdem, Gunhan
dc.contributor.authorDevecioglu, Omer
dc.contributor.authorGozukirmizi, Nermin
dc.date.accessioned2025-01-27T21:05:28Z
dc.date.available2025-01-27T21:05:28Z
dc.date.issued2011
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractWe investigated factor VIII (FVIII) gene mutations in 20 thrombosis patients with high level of FVIII and 20 control healthy participants. Blood samples were used for the determination of FVIII levels using static timing analyze (STA) kits. Informed consent forms were collected from all participants. Factor VIII level was 237 +/- 46 IU/dL in patients group; however, it was 122 +/- 38 IU/dL in healthy control participants. Isolated genomic DNAs were screened using 37 pairs of primers covering promoter region and 26 exons of FVIII gene. Single-strand conformation analysis (SSCA) technique was performed for polymorphism/mutation analyses. We observed polymorph patterns in exon 6, exon 13, exon 14F, exon 19, and exon 25 regions. However, we found no evidence of an association between observed single nucleotide polymorphisms and high thrombosis levels. In conclusion, observed exons polymorphisms do not seem to be associated with a venous thromboembolism.
dc.description.sponsorshipResearch Foundation Canakkale Onsekiz Mart University [2006-42]
dc.description.sponsorshipThis work was supported by the Research Foundation Canakkale Onsekiz Mart University Project No 2006-42, and performed at Istanbul University Molecular Biology and Genetics Department Laboratories.
dc.identifier.doi10.1177/1076029609349498
dc.identifier.endpage50
dc.identifier.issn1076-0296
dc.identifier.issue1
dc.identifier.pmid19825912
dc.identifier.scopus2-s2.0-78651381791
dc.identifier.scopusqualityQ2
dc.identifier.startpage46
dc.identifier.urihttps://doi.org/10.1177/1076029609349498
dc.identifier.urihttps://hdl.handle.net/20.500.12428/27659
dc.identifier.volume17
dc.identifier.wosWOS:000286071100006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSage Publications Inc
dc.relation.ispartofClinical and Applied Thrombosis-Hemostasis
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectthrombosis
dc.subjectfactor VIII level
dc.subjectpolymorphism
dc.subjectTurkish
dc.titleIs There Any Correlation Between The Elevated Plasma Levels and Gene Variations of Factor VIII in Turkish Thrombosis Patients?
dc.typeArticle

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