Letrozole usage adjuvant to gonadotropins for ovulation induction for patients with clomiphene citrate failure

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dc.contributor.authorOzdemir, Ulku
dc.contributor.authorOzaksit, Gulnur
dc.contributor.authorGungor, Ayse Nur Cakir
dc.contributor.authorAydogan, Munibe
dc.date.accessioned2025-01-27T20:22:47Z
dc.date.available2025-01-27T20:22:47Z
dc.date.issued2013
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractTo compare cycle properties of ovulation induction (OI) with gonadotropin alone or combined with letrozole in the patients with previous clomiphene citrate (CC) failure. In this prospective study, 40 patients with previous at least three times CC cycle failure were evaluated. Half of them received 2.5 mg letrozole on days 3-7 of the menstrual cycle and recombinant follicle stimulating hormone (rFSH) starting on day 5. The other half of the patients received only rFSH starting on day 3. Groups were compared according to the OI duration, gonadotropin dosage, endometrial thickness, estradiol (E2) levels on day of human chorionic gonadotropin (HCG) administration and follicle count. Total rFSH dose, the E2 levels on the day of HCG and > 18 mm follicle count was significantly lower and OI duration was significantly shorter in rFSH + letrozole group. Mean endometrial thickness was not different between groups. Adding letrozole to gonadotropin in OI cycles decreases total gonadotropin dose and induction duration without any adverse effects on endometrial thickness. Monoovulation is better achieved by adding letrozole to gonadotropin stimulation without decreasing pregnancy rates.
dc.identifier.doi10.1007/s00404-013-2780-5
dc.identifier.endpage448
dc.identifier.issn0932-0067
dc.identifier.issue2
dc.identifier.pmid23471549
dc.identifier.scopus2-s2.0-84880805508
dc.identifier.scopusqualityQ2
dc.identifier.startpage445
dc.identifier.urihttps://doi.org/10.1007/s00404-013-2780-5
dc.identifier.urihttps://hdl.handle.net/20.500.12428/22028
dc.identifier.volume288
dc.identifier.wosWOS:000321916200030
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer Heidelberg
dc.relation.ispartofArchives of Gynecology and Obstetrics
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectLetrozole
dc.subjectOvulation induction
dc.subjectGonadotropin
dc.subjectIntrauterine insemination
dc.titleLetrozole usage adjuvant to gonadotropins for ovulation induction for patients with clomiphene citrate failure
dc.typeArticle

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