The effects of apomorphine on paracetamol-induced hepatotoxicity in rats

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dc.authoridYayla, Muhammed/0000-0002-0659-3084
dc.authoridKARACA, Turan/0000-0002-2500-7781
dc.authoridBayir, Yasin/0000-0003-3562-6727
dc.authoridOztopuz, Ozlem/0000-0002-1373-6311
dc.contributor.authorSehitoglu, Muserref Hilal
dc.contributor.authorYayla, Muhammet
dc.contributor.authorKiraz, Asli
dc.contributor.authorOztopuz, Rahime Ozlem
dc.contributor.authorBayir, Yasin
dc.contributor.authorKaraca, Turan
dc.contributor.authorKhalid, Sumbul
dc.date.accessioned2025-01-27T20:11:52Z
dc.date.available2025-01-27T20:11:52Z
dc.date.issued2017
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractIt is becoming progressively more understandable that overdose of paracetamol in both humans and animals causes severe hepatotoxicity. Apomorphine is known as a neuroprotective agent. Due to the protective effect, apomorphine had been tested in experimental studies on different models. Findings obtained through series of expriments suggested that apomorphine may also be useful in liver toxicity. The aim of this study is to investigate the relationship among the hepatoprotective mechanism of apomorphine and to determine the possible role of apomorphine on paracetamol-induced hepatotoxicity in rats. 30 Sprague Dawley rats (adult male) were distributed into 5 groups. Group 1 was the control group and did not receive any medication. Group 2 received only paracetamol 2 g/kg by intragastric gavage to induce hepatotoxicity. Groups 3 and 4 were given apomorphine 1 mg/kg and 2 mg/kg by intraperitoneal injection, respectively. Groups 3 and 4 were given 2g/kg of Paracetamol. In Group 5, rats were treated with 2 mg/kg of apomorphine. Drug-treated rats were given food for the next 24 h until they were sacrified. Moreover, we also performed AST, ALT measurements in serum, MDA and SOD levels in liver tissues and histopathological analysis of the liver in all groups. Apomorphine had positive effects on both liver enzymes, oxidative stress markers and histopathological results in paracetamol-induced hepatotoxicity. Additionally, apomorphine at 2 mg/kg dose was significantly more protective as compared to 1 mg/kg as evidenced by the histopathological examination results. It was thought that apomorphine was found hepatoprotective on paracetamol-induced hepatotoxicity, especially at higher doses such as 2 mg/kg.
dc.identifier.doi10.14715/cmb/2017.63.12.10
dc.identifier.endpage44
dc.identifier.issn0145-5680
dc.identifier.issn1165-158X
dc.identifier.issue12
dc.identifier.pmid29307340
dc.identifier.scopus2-s2.0-85039993534
dc.identifier.scopusqualityQ4
dc.identifier.startpage40
dc.identifier.urihttps://doi.org/10.14715/cmb/2017.63.12.10
dc.identifier.urihttps://hdl.handle.net/20.500.12428/20762
dc.identifier.volume63
dc.identifier.wosWOS:000419272800010
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherC M B Assoc
dc.relation.ispartofCellular and Molecular Biology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectApomorphine
dc.subjectHepatotoxicity
dc.subjectParacetamol
dc.subjectRat
dc.titleThe effects of apomorphine on paracetamol-induced hepatotoxicity in rats
dc.typeArticle

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