Evaluation of left ventricular diastolic function by tissue Doppler imaging in patients with newly diagnosed and untreated primary generalized epilepsy

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dc.authoridMUDERRISOGLU, IBRAHIM HALDUN/0000-0002-9635-6313
dc.authoridYerdelen, Deniz/0000-0001-6799-5100
dc.contributor.authorBilgi, Muhammet
dc.contributor.authorYerdelen, Deniz
dc.contributor.authorColkesen, Yucel
dc.contributor.authorMuderrisoglu, Haldun
dc.date.accessioned2025-01-27T20:34:57Z
dc.date.available2025-01-27T20:34:57Z
dc.date.issued2013
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractPurpose: The effects of epilepsy and seizures on cardiac functions have been documented, and this association has drawn attention in recent years. The aim of this study was to investigate left ventricle (LV) diastolic function by tissue Doppler imaging (TDI) in patients with newly diagnosed and untreated primary generalized epilepsy (PGE). Method: Thirty newly diagnosed and untreated PGE patients (14 females, mean age 27.60 +/- 9.64 years) and 30 healthy age- and gender-matched control subjects (14 females, mean age 29.47 +/- 6.89 years) were included in the study. The LV functions of the study cohort were evaluated using conventional echocardiography and TDI. Results: There were no significant differences found between the two groups regarding the left atrium diameter, left atrium volume index, interventricular septum and posterior wall thickness, LV end diastolic diameter, and LV end diastolic:volume (p > 0.05 for each parameter). PGE patients exhibited a higher LV end systolic diameter and LV end systolic volume compared to the controls (p < 0.001 for each parameter). Thus, the fractional shortening and ejection fraction were lower in the PGE patients (p < 0.001 for each parameter). The E to average e' ratio, the most important noninvasive indicator of LV filling pressure, was significantly higher in patients with PGE (8.31 +/- 2.78 vs. 6.95 +/- 1.26, p = 0.018). Conclusion: The present study reports the systolic and diastolic dysfunction of LV in newly diagnosed PGE patients compared to control subjects. Taken together, the screening of epileptic patients using conventional echocardiography and TDI may be useful to evaluate the effects of epilepsy on cardiac functions. (C) 2013 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.
dc.identifier.doi10.1016/j.seizure.2013.03.015
dc.identifier.endpage541
dc.identifier.issn1059-1311
dc.identifier.issn1532-2688
dc.identifier.issue7
dc.identifier.pmid23623505
dc.identifier.scopus2-s2.0-84881138189
dc.identifier.scopusqualityQ2
dc.identifier.startpage537
dc.identifier.urihttps://doi.org/10.1016/j.seizure.2013.03.015
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23522
dc.identifier.volume22
dc.identifier.wosWOS:000323362500008
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherW B Saunders Co Ltd
dc.relation.ispartofSeizure-European Journal of Epilepsy
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectPrimary generalized epilepsy
dc.subjectDiastolic dysfunction
dc.subjectTissue Doppler imaging
dc.titleEvaluation of left ventricular diastolic function by tissue Doppler imaging in patients with newly diagnosed and untreated primary generalized epilepsy
dc.typeArticle

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