Subacute THYROiditis Related to SARS-CoV-2 VAccine and Covid-19 (THYROVAC Study): A Multicenter Nationwide Study

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dc.authorid0000-0003-0022-5704en_US
dc.authorid0000-0003-3590-2656en_US
dc.authorscopusid57220639037en_US
dc.authorscopusid56200500500en_US
dc.authorwosidK-8579-2019en_US
dc.authorwosidAAB-1936-2021en_US
dc.contributor.authorBatman, Adnan
dc.contributor.authorYazıcı, Dilek
dc.contributor.authorDikbaş, Oğuz
dc.contributor.authorAgbaht, Kemal
dc.contributor.authorSaygılı, Emre Sedar
dc.contributor.authorDemirci, İbrahim
dc.contributor.authorKarakılıç, Ersen
dc.date.accessioned2024-01-22T07:58:52Z
dc.date.available2024-01-22T07:58:52Z
dc.date.issued2023en_US
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractCONTEXT: The aims of the study are to compare characteristics of subacute thyroiditis (SAT) related to different etiologies, and to identify predictors of recurrence of SAT and incident hypothyroidism. METHODS: This nationwide, multicenter, retrospective cohort study included 53 endocrinology centers in Turkey. The study participants were divided into either COVID-19-related SAT (Cov-SAT), SARS-CoV-2 vaccine-related SAT (Vac-SAT), or control SAT (Cont-SAT) groups. RESULTS: Of the 811 patients, 258 (31.8%) were included in the Vac-SAT group, 98 (12.1%) in the Cov-SAT group, and 455 (56.1%) in the Cont-SAT group. No difference was found between the groups with regard to laboratory and imaging findings. SAT etiology was not an independent predictor of recurrence or hypothyroidism. In the entire cohort, steroid therapy requirement and younger age were statistically significant predictors for SAT recurrence. C-reactive protein measured during SAT onset, female sex, absence of antithyroid peroxidase (TPO) positivity, and absence of steroid therapy were statistically significant predictors of incident (early) hypothyroidism, irrespective of SAT etiology. On the other hand, probable predictors of established hypothyroidism differed from that of incident hypothyroidism. CONCLUSION: Since there is no difference in terms of follow-up parameters and outcomes, COVID-19- and SARS-CoV-2 vaccine-related SAT can be treated and followed up like classic SATs. Recurrence was determined by younger age and steroid therapy requirement. Steroid therapy independently predicts incident hypothyroidism that may sometimes be transient in overall SAT and is also associated with a lower risk of established hypothyroidism.en_US
dc.identifier.citationBatman, A., Yazıcı, D., Dikbaş, O., Ağbaht, K., Saygılı, E. S., Demirci, İ., … Şahin, M. (2023). Subacute THYROiditis Related to SARS-CoV-2 VAccine and Covid-19 (THYROVAC Study): A Multicenter Nationwide Study. The Journal of Clinical Endocrinology & Metabolism, 108(10), e1013–e1026. https://doi.org/10.1210/clinem/dgad235en_US
dc.identifier.doi10.1210/clinem/dgad235
dc.identifier.endpagee1026en_US
dc.identifier.issn0021-972X
dc.identifier.issn1945-7197
dc.identifier.issue10en_US
dc.identifier.pmid37186260
dc.identifier.scopus2-s2.0-85171601419
dc.identifier.startpagee1013en_US
dc.identifier.urihttps://doi.org/10.1210/clinem/dgad235
dc.identifier.urihttps://hdl.handle.net/20.500.12428/5286
dc.identifier.volume108en_US
dc.identifier.wosWOS:000999236300001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorSaygılı, Emre Sedar
dc.institutionauthorKarakılıç, Ersen
dc.language.isoen
dc.publisherNLM (Medline)en_US
dc.relation.ispartofThe Journal of clinical endocrinology and metabolismen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCOVID-19en_US
dc.subjectSARS-CoV-2 vaccineen_US
dc.subjectSubacute thyroiditisen_US
dc.titleSubacute THYROiditis Related to SARS-CoV-2 VAccine and Covid-19 (THYROVAC Study): A Multicenter Nationwide Study
dc.typeArticle

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