Electroanalytical and HPLC Methods for the Determination of Oxcarbazepine in Spiked Human Urine and Tablet Dosage Form

Basit Öğe Kaydı
dc.authoridYilmaz, Selehattin/0000-0003-4607-3523
dc.authoridSaglikoglu, Gulsen/0000-0002-3407-9787
dc.contributor.authorNosal-Wiercinska, Agnieszka
dc.contributor.authorYilmaz, Selehattin
dc.contributor.authorBinel, Sevcan
dc.contributor.authorYagmur, Sultan
dc.contributor.authorSaglikoglu, Gulsen
dc.contributor.authorSadikoglu, Murat
dc.contributor.authorYıldız, Mustafa
dc.date.accessioned2025-01-27T21:05:27Z
dc.date.available2025-01-27T21:05:27Z
dc.date.issued2014
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractIn this study, the electrochemical reduction and determination of oxcarbazepine were easily realized in various buffer solutions in the pH range of 4.50 to 11.15 in real samples using glassy carbon electrode (GCE) by cyclic voltammetric (CV) and differential pulse voltammetric (DPV) techniques. The influence of pH on the cathodic peak current and peak potential was investigated. Scan rate studies were also completed. The diffusion controlled nature of the peak was established. The best results for the quantitative determination of oxcarbazepine were obtained by DPV technique in Britton-Robinson (BR) buffer (pH 8.05). In this basic medium, one irreversible and sharp cathodic peak was observed. A linear calibration curve for DPV analysis was constructed in the oxcarbazepine concentration range of 8x10(-6) to 1x10(-4) M. Limit of detection (LOD) and limit of quantification (LOQ) were obtained as 1.65x10(-6) and 5.51x10(-6) M, respectively. Repeatability, reproducibility, precision and accuracy of the developed technique were checked in spiked human urine and tablet dosage forms by recovery studies and results of the high performance liquid chromatography (HPLC) technique. A reduction mechanism for the electrode reaction was proposed.
dc.identifier.doi10.5562/cca2046
dc.identifier.endpage219
dc.identifier.issn0011-1643
dc.identifier.issn1334-417X
dc.identifier.issue3
dc.identifier.scopus2-s2.0-84919773934
dc.identifier.scopusqualityQ4
dc.identifier.startpage213
dc.identifier.urihttps://doi.org/10.5562/cca2046
dc.identifier.urihttps://hdl.handle.net/20.500.12428/27655
dc.identifier.volume87
dc.identifier.wosWOS:000348414000004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherCroatian Chemical Soc
dc.relation.ispartofCroatica Chemica Acta
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectoxcarbazepine
dc.subjecthuman urine
dc.subjectdosage form
dc.subjectelectrochemical reduction
dc.subjectdetermination
dc.subjecthigh performance liquid chromatography (HPLC)
dc.titleElectroanalytical and HPLC Methods for the Determination of Oxcarbazepine in Spiked Human Urine and Tablet Dosage Form
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu