Association of abnormal coronary sinus reflux with coronary slow flow and importance of the Thebesian valve

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dc.contributor.authorAksit, Ercan
dc.contributor.authorBarutcu, Ahmet
dc.contributor.authorSehitoglu, Muserref Hilal
dc.contributor.authorKirilmaz, Bahadir
dc.contributor.authorArslan, Mehmet
dc.contributor.authorGazi, Emine
dc.contributor.authorTok, Ozge Ozden
dc.date.accessioned2025-01-27T20:47:34Z
dc.date.available2025-01-27T20:47:34Z
dc.date.issued2020
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground: The relationship between coronary slow flow (CSF) and coronary sinus (CS) reflux has not been previously studied. This study aimed to investigate the relationship between CSF and CS reflux and Thebesian valve presence as well as the relationship between CS reflux and serum annexin-V and ICAM-1 levels. Methods: In this case-control study, patients were divided into two groups: CSF (n = 13) and control (n = 7) groups. CS flow parameters and Thebesian valve presence were evaluated by cardiac magnetic resonance (CMR). Moreover, serum ICAM-1 and annexin-V levels were measured. Results: Regurgitation volume and regurgitation fraction, indicators of reflux flow in CS, were higher in the CSF group than in the control group (p = 0.039 and p = 0.019). Fewer Thebesian valves were observed in the CSF group than in the control group (p = 0.022). Furthermore, a positive correlation was found between regurgitation volume and regurgitation fraction and serum annexin-V and ICAM-1 levels (r = 0.813, p < 0.001 and r = 0.996, p < 0.001; r = 0.817, p < 0.001 and r = 0.993, p < 0.001, respectively). Conclusions: This study revealed the significant relationship between CSF and reflux flow in CS. The fact that the patients in the CSF group have fewer Thebesian valves suggests the importance of the valve in preventing backward flow from the coronary vein. A positive correlation between serum ICAM-1 and annexin-V levels with regurgitation volume and regurgitation fraction indicates that after a certain threshold, CS reflux should be considered an abnormal condition. (C) 2020 Elsevier B.V. All rights reserved.
dc.description.sponsorshipScientific Research Projects Coordination Unit of Canakkale Onsekiz Mart University [3049]
dc.description.sponsorshipThis research was supported by the Scientific Research Projects Coordination Unit of Canakkale Onsekiz Mart University as an Independent Research Project (Project ID: 3049). We would like to thank the radiology technicians in our hospital for their help during CMR imaging.
dc.identifier.doi10.1016/j.ijcard.2020.08.073
dc.identifier.endpage31
dc.identifier.issn0167-5273
dc.identifier.issn1874-1754
dc.identifier.pmid32858139
dc.identifier.scopus2-s2.0-85090309233
dc.identifier.scopusqualityQ1
dc.identifier.startpage26
dc.identifier.urihttps://doi.org/10.1016/j.ijcard.2020.08.073
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24964
dc.identifier.volume319
dc.identifier.wosWOS:000580586000005
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Ireland Ltd
dc.relation.ispartofInternational Journal of Cardiology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectCoronary sinus reflux
dc.subjectCoronary slow flow
dc.subjectThebesian valve
dc.subjectVascular waterfall
dc.titleAssociation of abnormal coronary sinus reflux with coronary slow flow and importance of the Thebesian valve
dc.typeArticle

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