Synthesis, FT-Raman, FT-IR, NMR spectroscopic characterization and antimicrobial activity of new mixed aza-oxo-thia macrocyclic compounds

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dc.authoridDulger, Basaran/0000-0002-3184-2652
dc.contributor.authorAghatabay, Naz Mohammed
dc.contributor.authorMahmiani, Yaghub
dc.contributor.authorCevik, Hueseyin
dc.contributor.authorGucin, Fahrettin
dc.contributor.authorDulger, Basaran
dc.date.accessioned2025-01-27T20:52:22Z
dc.date.available2025-01-27T20:52:22Z
dc.date.issued2008
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractSeries of new mixed aza-oxo-thia macrocyclic ligands {2,6,12,16-tetraaza-1,7,11,17-tetraoxo-9,19-dithia-[(4'-methyl-5',4,3')(14'-methyl-15',14,13')]ditriazine}cyclocosane (L-1 ); {2,6,13,17-teraaza-1,7,12,18-tetraoxo-9,10,20,21-tetrathia-[(4'-methyl-5',4,3')(15'-methyl-14',16',15)]di-triazine}cyclodocosane (L-2 ); {2,6,14,18-tetraaza-1,7,13,19-tetraoxo-10,22-dithia-[(4'-methyl-5',3',4)(16'-methyl-15',17',16)]ditriazine}cyclotetracosane (L-3 ) and {2,6,15,19-tetraaza-1,7,14,12-tetraoxo-10,11,23,24-tetrathia-[(4'-methyl-5',4,3')(17'-methyl-8',17,16')]ditriazine}cyclohexa-cosane (L-4 ) were synthesized. The structural features of the compounds have been studied by elemental analyses, Mass, FT-Raman, FT-IR, H-1 and C-13 NMR spectroscopy. The antimicrobial activities of the ligands were evaluated using disk diffusion method in dimethyl sulfoxide as well as the minimal inhibitory concentration (MIC) dilution method, against 9 bacteria. The obtained results from disk diffusion method were assessed in side-by-side comparison with those of Penicillin-g, Ampicillin, Cefotaxime, Vancomycin, Oflaxacin, and Tetracyclin, well-known antibacterial agents. The results from dilution procedure were compared with Gentamycin as antibacterial and Nystatin as antifungal. The antifungal activities are reported on five yeast cultures namely Candida albicans, Kluyveromyces fragilis, Rhodotorula rubra, Debaryomyces hansenii, and Hanseniaspora guilliermondii, and the results are referenced with Nystatin, Ketaconazole, and Clotrimazole, commercial antifungal agents. In most cases, the compounds show strong antifungal activity in the comparison tests.
dc.description.sponsorshipFatih University Scientific Research Centre [P50020702]
dc.description.sponsorshipWe would like to extend our gratitude to the Fatih University Scientific Research Centre for their financial support under projects (P50020702).
dc.identifier.doi10.1007/s11224-008-9373-0
dc.identifier.endpage842
dc.identifier.issn1040-0400
dc.identifier.issn1572-9001
dc.identifier.issue5
dc.identifier.scopus2-s2.0-53649099325
dc.identifier.scopusqualityQ2
dc.identifier.startpage833
dc.identifier.urihttps://doi.org/10.1007/s11224-008-9373-0
dc.identifier.urihttps://hdl.handle.net/20.500.12428/25746
dc.identifier.volume19
dc.identifier.wosWOS:000259922200018
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSpringer/Plenum Publishers
dc.relation.ispartofStructural Chemistry
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectDisk-diffusion
dc.subjectDilution
dc.subjectFT-Raman
dc.subjectGentamycin
dc.subjectInhibitory
dc.subjectTetracyclin
dc.titleSynthesis, FT-Raman, FT-IR, NMR spectroscopic characterization and antimicrobial activity of new mixed aza-oxo-thia macrocyclic compounds
dc.typeArticle

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