Increased Levels of Serum Ischemia Modified Albumin in Patients with Ankylosing Spondylitis

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dc.contributor.authorTurkon, Hakan
dc.contributor.authorGokmen, Ferhat
dc.contributor.authorCakir, Dilek Ulker
dc.contributor.authorSehitoglu, Muserref Hilal
dc.contributor.authorResorlu, Hatice
dc.contributor.authorDoner, Davut
dc.contributor.authorEssizoglu, Ertan
dc.date.accessioned2025-01-27T20:55:50Z
dc.date.available2025-01-27T20:55:50Z
dc.date.issued2016
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground: The aim of the study was to investigate oxidant/antioxidant status by determining serum ischemia-modified albumin (IMA) levels with oxidative/antioxidant parameters in patients with ankylosing spondylitis (AS) compared to the controls. Methods: The serum concentrations of IMA, IMA/albumin ratio (IMAR), malondialdehyde (MDA), total oxidant status (TOS), oxidative stress index (OSI), superoxide dismutase (SOD), glutathione peroxidase (GPx), and total antioxidant capacity (TAC) were measured in 40 AS patients and 35 healthy controls. Results: Mean serum IMA, IMAR, MDA, TOS, and OSI levels were increased in patients with AS when compared to the control group (p < 0.05 for all). Serum levels of SOD and GPx were significantly lower in the patient group than in the healthy subjects (p < 0.001 for both). Serum TAC levels were decreased in patients with AS compared to the controls but the statistical difference was not significant. Serum IMA levels were found to be positively correlated with BASDAI, BASFI, BASMI, and ASDAS-CRP (r = 0.356, r = 0.370, r = 0.412, r = 0.353, respectively, and p < 0.05 for all). IMAR values showed significant correlations with BASFI, BASMI, and ASDAS-CRP (r = 0.351, p = 0.026; r = 0.400, p = 0.010; and r = 0.379, p = 0.016, respectively). Conclusions: Depletion in antioxidant systems and overproduction of free radicals leading to formation of the oxidative stress may play a role in the development of AS. Increased levels of IMA might provide important contributions to the underlying oxidative stress in AS.
dc.description.sponsorshipCanakkale Onsekiz Mart University Scientific Research Projects Commission [TSA-2014-195]
dc.description.sponsorshipThis study was supported by the Canakkale Onsekiz Mart University Scientific Research Projects Commission (Project no. TSA-2014-195).
dc.identifier.doi10.7754/Clin.Lab.2015.150815
dc.identifier.endpage649
dc.identifier.issn1433-6510
dc.identifier.issue4
dc.identifier.pmid27215084
dc.identifier.scopus2-s2.0-84971414174
dc.identifier.scopusqualityQ3
dc.identifier.startpage645
dc.identifier.urihttps://doi.org/10.7754/Clin.Lab.2015.150815
dc.identifier.urihttps://hdl.handle.net/20.500.12428/26200
dc.identifier.volume62
dc.identifier.wosWOS:000373864200018
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherClin Lab Publ
dc.relation.ispartofClinical Laboratory
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectankylosing spondylitis
dc.subjectischemia-modified albumin
dc.subjectoxidative stress
dc.subjectinflammation
dc.titleIncreased Levels of Serum Ischemia Modified Albumin in Patients with Ankylosing Spondylitis
dc.typeArticle

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