The neuroprotective effect of Sulindac after ischemia-reperfusion injury in rats1

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dc.authoridguven, mustafa/0000-0001-8643-9775
dc.authoridAras, Adem Bozkurt/0000-0002-0140-5224
dc.contributor.authorCosar, Murat
dc.contributor.authorKaner, Tuncay
dc.contributor.authorSahin, Onder
dc.contributor.authorTopaloglu, Naci
dc.contributor.authorGuven, Mustafa
dc.contributor.authorAras, Adem Bozkurt
dc.contributor.authorAkman, Tarik
dc.date.accessioned2025-01-27T20:31:25Z
dc.date.available2025-01-27T20:31:25Z
dc.date.issued2014
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractPURPOSE:To investigate the neuroprotective effects of Sulindac on the hippocampal complex after global cerebral ischemia/reperfusion (I/R) injury in rats. METHODS: Thirty one Sprague- Dawley rats were used, distributed into group I (sham) n: 7 were used as control. For group II (n: 8), III (n: 8) and IV (n: 8) rats, cerebral ischemia was performed via the occlusion of bilateral internal carotid artery for 45 minutes and continued with reperfusion process. 0.3 mL/kg/h 0.9 % sodium chloride was infused intraperitoneally to the Group II rats before ischemia, 5 mu g/kg/h/0.3 ml sulindac was infused intraperitoneally to the Group III rats before ischemia and 5 mu g/kg/h/0.3 ml sulindac was infused intraperitoneally to the Group IV rats after ischemia and before reperfusion process. The levels of MDA, GSH and MPO activity were measured in the left hippocampus tissue. The hippocampal tissue of all group members were taken for histopathological study. RESULTS: The MDA and MPO levels increased from group I (control) to group II (I/R) (P < 0.05) and decreased from group II (I/R) to group III (presulindac + I/R) and IV (postsulindac + I/R) (P < 0.05). Beside these, the GSH levels decreased from group I (control) to group II (I/R) (P < 0.05) and increased from group II (I/R) to group III (presulindac + I/R) and IV (postsulindac + I/R) (P < 0.05). The number of apoptotic neurons increased from group I (control) to group II (I/R) (P < 0.05) and decreased from group II (I/R) to group III (presulindac + I/R) and IV (postsulindac + I/R) (P < 0.05). CONCLUSION: The Sulindac may have neuroprotective effects on ischemic neural tissue to prevent the reperfusion injury after ischemia.
dc.identifier.doi10.1590/S0102-86502014000400008
dc.identifier.endpage273
dc.identifier.issn0102-8650
dc.identifier.issn1678-2674
dc.identifier.issue4
dc.identifier.pmid24760028
dc.identifier.scopus2-s2.0-84898840434
dc.identifier.scopusqualityQ2
dc.identifier.startpage268
dc.identifier.urihttps://doi.org/10.1590/S0102-86502014000400008
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23143
dc.identifier.volume29
dc.identifier.wosWOS:000334997000008
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherActa Cirurgica Brasileira
dc.relation.ispartofActa Cirurgica Brasileira
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectReperfusion Injury
dc.subjectNeuroprotective Agents
dc.subjectSulindac
dc.subjectRats
dc.subjectSprague-Dawley
dc.titleThe neuroprotective effect of Sulindac after ischemia-reperfusion injury in rats1
dc.typeArticle

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