Exploring Gender Differences in the Effects of Diet and Physical Activity on Metabolic Parameters
dc.authorid | Padua, Elvira/0000-0001-5227-2567 | |
dc.authorid | Caprio, Massimiliano/0000-0003-0722-7163 | |
dc.authorid | Gorini, Stefania/0000-0003-4182-9942 | |
dc.authorid | Aulisa, Giovanni/0000-0002-8593-8051 | |
dc.authorid | Lombardo, Mauro/0000-0001-7509-5487 | |
dc.authorid | Cava, Edda/0000-0002-8186-039X | |
dc.authorid | ARMANI, Andrea/0000-0002-2130-1596 | |
dc.contributor.author | Gorini, Stefania | |
dc.contributor.author | Camajani, Elisabetta | |
dc.contributor.author | Feraco, Alessandra | |
dc.contributor.author | Armani, Andrea | |
dc.contributor.author | Karav, Sercan | |
dc.contributor.author | Filardi, Tiziana | |
dc.contributor.author | Aulisa, Giovanni | |
dc.date.accessioned | 2025-05-29T02:57:22Z | |
dc.date.available | 2025-05-29T02:57:22Z | |
dc.date.issued | 2025 | |
dc.department | Çanakkale Onsekiz Mart Üniversitesi | |
dc.description.abstract | Background: Gender differences in metabolic response to lifestyle interventions remain poorly explored. This study aimed to evaluate the impact of a six-month Mediterranean diet (MD) intervention combined with regular physical activity on metabolic parameters in overweight adults. Methods: A prospective cohort study was conducted in an obesity clinic in Rome, Italy, involving overweight adults (BMI >= 25 kg/m2) motivated to improve their lifestyle. Participants (n = 205; 107 men and 98 women) self-selected into physical activity groups (aerobic, anaerobic, combined or no activity). Gender-specific metabolic changes were assessed, including lipid profiles, liver markers and fasting glucose. Results: Significant gender differences in metabolic results were observed. Men showed greater reductions in total cholesterol (TC) and LDL, as well as significant reductions in alanine aminotransferase (ALT). Women showed a significant increase in HDL cholesterol. Fasting blood glucose decreased significantly in both sexes, with no differences between the sexes. Activity-specific analysis revealed that anaerobic activity significantly improved lipid metabolism in men, while aerobic activity produced the greatest benefits in women, including increased HDL and improved liver marker profiles. Conclusions: Therapeutic strategies combining MD and physical activity must take into account gender-specific physiological differences and the type of sport activity to optimise metabolic benefits. Personalised approaches may improve the management of cardiovascular risk factors in overweight individuals. Study registration: This study is registered on ClinicalTrials.gov (NCT06661330). | |
dc.description.sponsorship | IRCCS San Raffaele Pisana; IRCCS San Raffaele Pisana (Ricerca Corrente) | |
dc.description.sponsorship | This work was supported by institutional fundings from IRCCS San Raffaele Pisana (Ricerca Corrente). | |
dc.identifier.doi | 10.3390/nu17020354 | |
dc.identifier.issn | 2072-6643 | |
dc.identifier.issue | 2 | |
dc.identifier.pmid | 39861484 | |
dc.identifier.scopus | 2-s2.0-85215774311 | |
dc.identifier.scopusquality | Q1 | |
dc.identifier.uri | https://doi.org/10.3390/nu17020354 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12428/30033 | |
dc.identifier.volume | 17 | |
dc.identifier.wos | WOS:001404161900001 | |
dc.identifier.wosquality | Q1 | |
dc.indekslendigikaynak | Web of Science | |
dc.indekslendigikaynak | Scopus | |
dc.indekslendigikaynak | PubMed | |
dc.language.iso | en | |
dc.publisher | MDPI | |
dc.relation.ispartof | Nutrients | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.snmz | KA_WOS_20250529 | |
dc.subject | gender differences | |
dc.subject | Mediterranean diet | |
dc.subject | physical activity | |
dc.subject | metabolic parameters | |
dc.subject | cholesterol | |
dc.subject | liver enzymes | |
dc.subject | sport | |
dc.subject | therapeutic customisation | |
dc.title | Exploring Gender Differences in the Effects of Diet and Physical Activity on Metabolic Parameters | |
dc.type | Article |