Electrocardiography changes in bipolar patients during long-term lithium monotherapy

Basit Öğe Kaydı
dc.authoridGuloksuz, Sinan/0000-0002-6626-1874
dc.contributor.authorAltinbas, Kursat
dc.contributor.authorGuloksuz, Sinan
dc.contributor.authorCaglar, Ilker Murat
dc.contributor.authorCaglar, Fatma Nihan Turhan
dc.contributor.authorKurt, Erhan
dc.contributor.authorOral, Esat Timucin
dc.date.accessioned2025-01-27T20:58:09Z
dc.date.available2025-01-27T20:58:09Z
dc.date.issued2014
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective: Cardiovascular side effects of lithium have been reported to occur mainly at higher-than-therapeutic serum levels. We aimed to investigate the impact of the long-term lithium use on electrocardiogram (ECG) parameters in association with the serum levels in patients with bipolar disorder (BD) and in healthy controls (HCs) serving as the reference group. Methods: The study sample consisted of 53 euthymic BD type I patients on lithium monotherapy at therapeutic serum levels (M=0.76, S.D.=0.14, range=0.41-1.09 mmol/l) for at least 12 months and 45 HCs. A 12-lead surface ECG was obtained from all participants at resting state for at least half an hour for 5-min recording. Heart-rate, Pmax, Pmin, QRS interval, QT dispersion, QT dispersion ratio (QTdR) and Tpeak-to-end interval (TpTe) were measured. Results: Regression analyses revealed that QTdR (B=14.17, P=.001), TpTe (B=18.38, P<.001), Pmax (B=17.84, P<.001) and Pmin (B=25.10, P<.001) were increased in BD patients who were on chronic lithium treatment than in HCs after controlling for age, sex and strict Bonferroni correction for multiple testing. There were no associations between serum lithium levels and ECG parameters. Conclusion: Our findings suggest that the use of lithium is associated with both atrial and ventricular electrical instability, even when lithium levels are in the therapeutic range. (C) 2014 Elsevier Inc. All rights reserved.
dc.description.sponsorshipEuropean Community [HEALTH-F2-2009-241909]
dc.description.sponsorshipWe would like to thank Prof. Willem Nolen who kindly reviewed the article and shared his comments on the article. S. G. would like to thank the support of the European Community's Seventh Framework Programme under grant agreement no. HEALTH-F2-2009-241909 (Project EU-GEI).
dc.identifier.doi10.1016/j.genhosppsych.2014.07.001
dc.identifier.endpage697
dc.identifier.issn0163-8343
dc.identifier.issn1873-7714
dc.identifier.issue6
dc.identifier.pmid25091141
dc.identifier.scopus2-s2.0-84919446168
dc.identifier.scopusqualityQ1
dc.identifier.startpage694
dc.identifier.urihttps://doi.org/10.1016/j.genhosppsych.2014.07.001
dc.identifier.urihttps://hdl.handle.net/20.500.12428/26625
dc.identifier.volume36
dc.identifier.wosWOS:000345434400026
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Inc
dc.relation.ispartofGeneral Hospital Psychiatry
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectBipolar disorder
dc.subjectLithium
dc.subjectECG
dc.subjectQT interval
dc.subjectArrhythmia
dc.titleElectrocardiography changes in bipolar patients during long-term lithium monotherapy
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu