Is abnormal glucose metabolism during pregnancy related to endothelial dysfunction?

Basit Öğe Kaydı
dc.contributor.authorGungor, Omer
dc.contributor.authorGazi, Emine
dc.contributor.authorOzkececi, Gulay
dc.contributor.authorGungor, Ayse Nur Cakir
dc.contributor.authorCevizci, Sibel
dc.contributor.authorHacivelioglu, Servet
dc.contributor.authorTemiz, Ahmet
dc.date.accessioned2025-01-27T20:31:22Z
dc.date.available2025-01-27T20:31:22Z
dc.date.issued2015
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective: Endothelial dysfunction is an independent risk factor for cardiovascular events. We aimed to investigate the relationship between endothelial dysfunction and gestational diabetes mellitus and impaired glucose tolerance. Methods: Pregnant women who had impaired glucose metabolism in the 75-g oral glucose tolerance test (OGTT) and their age-and body mass index-matched controls were included in the study and assessed for flow-mediated vasodilatation to evaluate endothelial dysfunction. Results: A total of 51 patients participated in the study. There were 20 patients in the control group, 13 in the impaired glucose tolerance group and 18 in the gestational diabetes mellitus group. Flow-mediated vasodilatation measured at the 60th and 120th seconds were significantly lower in the impaired glucose tolerance and gestational diabetes mellitus groups than in the control group (8.5 +/- 5.7 and 8.9 +/- 6.5 versus 14.9 +/- 9.0, p = 0.022 and 6.2 +/- 6.7 and 5.2 +/- 5.0 versus 12.0 +/- 8.3, p = 0.011, respectively). Conclusions: Patients with gestational diabetes mellitus and impaired glucose tolerance have impaired endothelial dysfunction. Delivery might have protective effects on endothelial functions. The significance of impaired endothelial dysfunction for pregnant women must be investigated, and if needed, lifestyle changes might be suggested, according to the determined importance of the endothelial dysfunction.
dc.identifier.doi10.3109/14767058.2014.906574
dc.identifier.endpage185
dc.identifier.issn1476-7058
dc.identifier.issn1476-4954
dc.identifier.issue2
dc.identifier.pmid24646337
dc.identifier.scopus2-s2.0-84920054583
dc.identifier.scopusqualityQ1
dc.identifier.startpage182
dc.identifier.urihttps://doi.org/10.3109/14767058.2014.906574
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23114
dc.identifier.volume28
dc.identifier.wosWOS:000346922300013
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofJournal of Maternal-Fetal & Neonatal Medicine
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectEndothelial dysfunction
dc.subjectgestational diabetes
dc.subjectpregnancy
dc.titleIs abnormal glucose metabolism during pregnancy related to endothelial dysfunction?
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu