Effects of folic acid on testicular toxicity induced by bisphenol-A in male Wistar rats

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dc.authoridGules, Ozay/0000-0001-6170-1706
dc.authoridYıldız, Mustafa/0000-0003-4128-8947
dc.contributor.authorGules, O.
dc.contributor.authorYildiz, M.
dc.contributor.authorNaseer, Z.
dc.contributor.authorTatar, M.
dc.date.accessioned2025-01-27T20:20:14Z
dc.date.available2025-01-27T20:20:14Z
dc.date.issued2019
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractWe investigated the protective effect of the folic acid (FA) against bisphenol-A (BPA) induced toxicity in rat testis. We used four groups of seven adult male Wistar albino rats. The control group was fed corn oil, the BPA group was given BPA, the FA group was given FA and the FA + BPA group was given FA initially followed by BPA 1 h later. The BPA, FA and corn oil were administered by oral gavage for 14 days. At the end of the experiment, testis sections were examined for histological and histomorphometric characteristics. The TUNEL method was used to detect apoptosis and immunohistochemistry was used to examine the distribution of spermatogonial stem cells. Levels of serum testosterone were measured, and sperm viability and morphology were determined. The histological structure of the testis was normal in the control and FA groups. Although the number of TUNEL positive cells/tubule increased, the seminiferous epithelium height (SEH) at stages VII-VIII decreased in the BPA group compared to the control, FA and FA + BPA groups. The number of TUNEL positive cells/tubule decreased and the SEH at stages VII-VIII increased in the FA + BPA group compared to the BPA group. No significant difference in spermatogonial stem cells was found among groups. The level of serum testosterone and percentage of viable sperm was significantly lower, while the head, midpiece and total sperm abnormalities were significantly higher in the BPA treated group compared to control, FA, FA + BPA groups. It appears that the toxic effects of BPA on testis might be minimized by FA treatment.
dc.identifier.doi10.1080/10520295.2018.1493222
dc.identifier.endpage35
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue1
dc.identifier.pmid30079777
dc.identifier.scopus2-s2.0-85052059880
dc.identifier.scopusqualityQ2
dc.identifier.startpage26
dc.identifier.urihttps://doi.org/10.1080/10520295.2018.1493222
dc.identifier.urihttps://hdl.handle.net/20.500.12428/21632
dc.identifier.volume94
dc.identifier.wosWOS:000458977400004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofBiotechnic & Histochemistry
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectBisphenol A
dc.subjectfolic acid
dc.subjecthistomorphometry
dc.subjectrat
dc.subjectsperm abnormality
dc.subjecttestis
dc.titleEffects of folic acid on testicular toxicity induced by bisphenol-A in male Wistar rats
dc.typeArticle

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