Profiles of primary brain abscesses and their impact on survival: An international ID-IRI study

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dc.authoridCascio, Antonio/0000-0002-1992-1796
dc.authoridUnver Ulusoy, Tulay/0000-0002-0172-2326
dc.authoridErdem, Hakan/0000-0002-6265-5227
dc.authoridMarino, Andrea/0000-0002-5650-6911
dc.authoridAlavi Darazam, Ilad/0000-0002-4440-335X
dc.authoridSahin, Meyha/0000-0003-4147-3587
dc.authoridRahimi, Bilal Ahmad/0000-0002-6630-5742
dc.contributor.authorSahin, Meyha
dc.contributor.authorMert, Ali
dc.contributor.authorEmecen, Ahmet Naci
dc.contributor.authorStrunjas, Natalija Planinc
dc.contributor.authorFasanekova, Lenka
dc.contributor.authorBatirel, Ayse
dc.contributor.authorDarazam, Ilad Alavi
dc.date.accessioned2025-01-27T20:38:57Z
dc.date.available2025-01-27T20:38:57Z
dc.date.issued2024
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjectives: This study of 331 primary brain abscess (PBA) patients aimed to understand infecting agents, predisposing factors, and outcomes, with a focus on factors affecting mortality. Methods: Data were collected from 39 centers across 16 countries between January 2010 and December 2022, and clinical, radiological, and microbiological findings, along with their impact on mortality, were analyzed. Results: The patients had a mean +/- SD age of 46.8 +/- 16.3 years, with a male predominance of 71.6%. Common symptoms included headache (77.9%), fever (54.4%), and focal neurological deficits (53.5%). Gram-positive cocci were the predominant pathogens, with Viridans group streptococci identified as the most frequently isolated organisms. All patients received antimicrobial therapy and 71.6% underwent interventional therapies. The 42-day and 180-day survival rates were 91.9% and 86.1%, respectively. Significant predictors of 42-day mortality included intravenous drug addiction (HR: 6.02, 95% CI: 1.38-26.26), malignancy (HR: 3.61, 95% CI: 1.23-10.58), confusion (HR: 2.65, 95% CI: 1.19-5.88), and unidentified bacteria (HR: 4.68, 95% CI: 1.76-12.43). Significant predictors of 180-day mortality included malignancy (HR: 2.70, 95% CI: 1.07-6.81), confusion (HR: 2.14, 95% CI: 1.11-4.15), temporal lobe involvement (HR: 2.10, 95% CI: 1.08-4.08), and unidentified bacteria (HR: 3.02, 95% CI: 1.49-6.15). Conclusion: The risk of death in PBA extends beyond the infection phase, with different factors influencing the 42-day and 180-day mortality rates. Intravenous drug addiction was associated with early mortality, while temporal lobe involvement was associated with late mortality. (c) 2024 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ )
dc.identifier.doi10.1016/j.ijid.2024.107228
dc.identifier.issn1201-9712
dc.identifier.issn1878-3511
dc.identifier.pmid39216784
dc.identifier.scopus2-s2.0-85203648875
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.ijid.2024.107228
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23816
dc.identifier.volume147
dc.identifier.wosWOS:001318567900001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Sci Ltd
dc.relation.ispartofInternational Journal of Infectious Diseases
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectIntravenous drug addiction
dc.subjectMicrobiological findings
dc.subjectMortality
dc.subjectPrimary brain abscesses
dc.subjectTemporal lobe involvement
dc.titleProfiles of primary brain abscesses and their impact on survival: An international ID-IRI study
dc.typeArticle

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