Clinical Profiles and In-Hospital Outcomes of Pre-Existing Versus Newly Diagnosed Atrial Fibrillation in Coronary Care Units: Insights From the MORCOR-TURK National Registry

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dc.authorid0000-0002-7280-5137
dc.authorid0000-0003-4669-7387
dc.contributor.authorAydin, Ertan
dc.contributor.authorOgutveren, Muhammed Mursel
dc.contributor.authorMert, Gurbet Ozge
dc.contributor.authorYeni, Mehtap
dc.contributor.authorGulasti, Sevil
dc.contributor.authorKucuk, Ugur
dc.contributor.authorCandemir, Basar
dc.date.accessioned2026-02-03T12:03:18Z
dc.date.available2026-02-03T12:03:18Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective To compare demographic, clinical, and laboratory profiles and short-term outcomes between pre-existing (chronic) atrial fibrillation (AF) and newly diagnosed AF among patients admitted to coronary care units (CCUs) in Turkey, and to identify factors associated with in-hospital mortality within AF subtypes. Methods This multicenter, prospective national registry analysis included 540 consecutive AF patients from 50 CCU centers across seven geographic regions in Turkey (MORCOR-TURK National Registry; September 1-30, 2022). Patients were categorized as pre-existing AF (documented AF prior to or at admission) or newly diagnosed AF (first detected during hospitalization). Demographics, comorbidities, admission diagnoses, laboratory biomarkers (including NT-proBNP and hs-troponin I), management, and outcomes were recorded. Multivariable logistic regression identified independent predictors of in-hospital mortality. Results Pre-existing AF (n = 324) had higher prevalences of diabetes mellitus (42.3% vs. 31.5%; p = 0.012) and acute coronary syndromes (58.6% vs. 34.7%; p < 0.001). Newly diagnosed AF (n = 216) more frequently presented with heart failure (45.8% vs. 28.4%; p < 0.001) and dyspnea (67.1% vs. 48.5%; p < 0.001). Newly diagnosed AF exhibited higher inflammatory burden (CRP median 28.4 vs. 12.6 mg/L; p < 0.001) and lower hemoglobin (11.8 +/- 2.1 vs. 12.9 +/- 1.8 g/dL; p < 0.001). NT-proBNP was elevated in both groups and higher in newly diagnosed AF (median 4850 vs. 3240 pg/mL; p = 0.003). In-hospital mortality was greater with newly diagnosed AF (12.0% vs. 6.8%; p = 0.042). Independent mortality predictors included age, chronic kidney disease, cardiogenic shock, and log-transformed NT-proBNP, hs-troponin I, and CRP. Conclusion In Turkish CCUs, pre-existing and newly diagnosed AF constitute distinct clinical phenotypes with differing presentations, biomarker profiles, and short-term risk. Newly diagnosed AF is associated with greater inflammatory and hemodynamic stress and higher in-hospital mortality. Biomarker-enriched risk stratification may refine prognostication and guide targeted management within AF subtypes.
dc.description.sponsorshipTurkish Society of Cardiology research grants program
dc.description.sponsorshipThis study was supported by the Turkish Society of Cardiology research grants program.
dc.identifier.doi10.1002/joa3.70238
dc.identifier.issn1880-4276
dc.identifier.issn1883-2148
dc.identifier.issue6
dc.identifier.pmid41321756
dc.identifier.scopus2-s2.0-105023304912
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1002/joa3.70238
dc.identifier.urihttps://hdl.handle.net/20.500.12428/35003
dc.identifier.volume41
dc.identifier.wosWOS:001651567300032
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Arrhythmia
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20260130
dc.subjectatrial fibrillation
dc.subjectbiomarkers
dc.subjectcoronary care unit
dc.subjectmortality
dc.subjectnational registry
dc.subjectnewly diagnosed AF
dc.subjectpre-existing AF
dc.titleClinical Profiles and In-Hospital Outcomes of Pre-Existing Versus Newly Diagnosed Atrial Fibrillation in Coronary Care Units: Insights From the MORCOR-TURK National Registry
dc.typeArticle

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