Effect of Alpha Lipoic Acid on Polychlorinated Biphenyl (Aroclor 1254)-Induced Nephrotoxicity in Rats

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dc.authoridYıldız, Mustafa / 0000-0003-4128-8947
dc.contributor.authorYıldız, Mustafa
dc.date.accessioned2025-01-27T19:30:22Z
dc.date.available2025-01-27T19:30:22Z
dc.date.issued2023
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractThe present study aimed to determine the morphological changes in rat kidneys exposed to PCB (Aroclor 1254) and to reveal the effects of ALA on those changes. Rats were randomly divided into four groups: Control, ALA, PCB and ALA+PCB. The applications of ALA and PCB continued for thirty days. At the end of the experiment, the tissue samples were taken from the animals. Crossmon’s triple staining method was applied to kidney sections for histopathological and histomorphometric examinations. In addition, the periodic acid-Schiff (PAS) reaction was examined in tissue sections. Histopathologically, it was determined that glomerular degeneration and connective tissue densities in the kidney significantly increased in PCB group compared to Control group. Besides, it was found that glomerular degeneration intensity significantly decreased in ALA+PCB group compared to PCB group. It was detected that the diameters of the renal corpuscle, proximal tubule, ascending limb of Henle’s loop and collecting duct in the kidney significantly decreased in PCB group compared to Control group. However, these parameters significantly increased in ALA+PCB group compared to PCB group. While the density of glomerular mesangial matrix and glycogen density in proximal tubule epithelium significantly increased in PCB group compared to Control group, these parameters significantly decreased in ALA+PCB group compared to PCB group. As a result, PCB may adversely affect renal functions by causing disorders in kidney histology. In addition, the use of ALA against PCB exposure may contribute to the preservation of kidney tissue.
dc.identifier.doi10.30607/kvj.1364111
dc.identifier.endpage512
dc.identifier.issn1308-1594
dc.identifier.issn2147-6853
dc.identifier.issue4
dc.identifier.startpage504
dc.identifier.trdizinid1221469
dc.identifier.urihttps://doi.org/10.30607/kvj.1364111
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1221469
dc.identifier.urihttps://hdl.handle.net/20.500.12428/16093
dc.identifier.volume16
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherAfyon Kocatepe University
dc.relation.ispartofKocatepe Veterinary Journal
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_TRD_20250125
dc.subjectAlpha lipoic acid
dc.subjectAroclor 1254
dc.subjectHistology
dc.subjectKidney
dc.subjectRat
dc.subjectAlfa lipoik asit
dc.subjectAroklor 1254
dc.subjectBöbrek
dc.subjectHistoloji
dc.subjectSıçan
dc.titleEffect of Alpha Lipoic Acid on Polychlorinated Biphenyl (Aroclor 1254)-Induced Nephrotoxicity in Rats
dc.title.alternativeSıçanlarda Poliklorlu Bifenil (Aroklor 1254) ile Oluşturulan Nefrotoksisite Üzerine Alfa Lipoik Asitin Etkisi
dc.typeArticle

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