The effects of dexmedetomidine on mesenteric arterial occlusion-associated gut ischemia and reperfusion-induced gut and kidney injury in rabbits

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dc.authoridSELEK, Sahabettin/0000-0003-1235-3957
dc.authoridArslan Yurtlu, Derya/0000-0002-7250-1256
dc.authoridSozmen, Mahmut/0000-0001-7976-4051
dc.authoridHanci, Volkan/0000-0002-2227-194X
dc.authoridYurtlu, Serhan/0000-0003-3020-1586
dc.contributor.authorKilic, Kemal
dc.contributor.authorHanci, Volkan
dc.contributor.authorSelek, Sahbettin
dc.contributor.authorSozmen, Mahmut
dc.contributor.authorKilic, Nergiz
dc.contributor.authorCitil, Mehmet
dc.contributor.authorYurtlu, Derya Arslan
dc.date.accessioned2025-01-27T20:39:19Z
dc.date.available2025-01-27T20:39:19Z
dc.date.issued2012
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective: We assessed the antioxidant activity of dexmedetomidine (Dex) administered during the ischemic period in a rabbit model of mesenteric ischemia/reperfusion (I/R) injury using biochemical and histopathological methods. Methods: A total of 24 male New Zealand white rabbits weighing between 2.5 and 3.0 kg were randomly divided into three groups: the sham group (Group S, n = 8), the I/R group (Group I/R, n = 8), and the I/R plus Dex treatment group (Group Dex, n = 8). In the I/R group, ischemia was achieved with 60 min of mesenteric occlusion. The sham group provided normal basal values. The rabbits in Group I/R were operated to achieve I/R. Group Dex received intravenous Dex 30 min after the commencement of reperfusion (10 mu g/kg Dex was infused within 10 min, and then a maintenance dose of 10 mu g/kg/h Dex was infused intravenously). For the measurement of tissue malondialdehyde, total antioxidant status, total oxidant status, lipid hydroperoxide levels, superoxide dismutase, catalase, and myeloperoxidase activity levels in the renal tissue samples of animals, the rabbits in each group were sacrificed 3 h after reperfusion. The histopathological examination scores were determined using the intestinal and renal tissues. Results: The mean malondialdehyde, total oxidant status, myeloperoxidase, and lipid hydroperoxide levels were significantly higher in Group I/R than in Groups S and Dex (P < 0.05). There also were significant decreases in the mean total antioxidant status, catalase, and superoxide dismutase activities in Group I/R compared with Groups S and Dex (P < 0.05). The histopathological examination scores of the intestinal and renal tissues were significantly higher in Group I/R compared with Groups S and Dex (P < 0.05). Conclusion: Dex treatment may have biochemical and histopathological benefits by preventing I/R-related cellular damage of intestinal and renal tissues as shown in an experimental mesenteric ischemia model. The preference to use Dex for anesthesia during the mesenteric ischemia procedure may attenuate I/R injury in intestinal and renal tissues. (C) 2012 Elsevier Inc. All rights reserved.
dc.identifier.doi10.1016/j.jss.2012.03.073
dc.identifier.endpage232
dc.identifier.issn0022-4804
dc.identifier.issue1
dc.identifier.pmid22560540
dc.identifier.scopus2-s2.0-84868199192
dc.identifier.scopusqualityQ1
dc.identifier.startpage223
dc.identifier.urihttps://doi.org/10.1016/j.jss.2012.03.073
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23919
dc.identifier.volume178
dc.identifier.wosWOS:000310450300038
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAcademic Press Inc Elsevier Science
dc.relation.ispartofJournal of Surgical Research
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectExperimental mesenteric ischemia
dc.subjectDexmedetomidine
dc.subjectRenal
dc.subjectIntestinal
dc.subjectRabbit
dc.subjectMesenteric artery occlusion
dc.titleThe effects of dexmedetomidine on mesenteric arterial occlusion-associated gut ischemia and reperfusion-induced gut and kidney injury in rabbits
dc.typeArticle

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