Voltammetric Determination of Acyclovir in Human Urine Using Ultra Trace Graphite and Glassy Carbon Electrodes

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dc.authoridYilmaz, Selehattin/0000-0003-4607-3523
dc.authoridSaglikoglu, Gulsen/0000-0002-3407-9787
dc.contributor.authorSadikoglu, Murat
dc.contributor.authorSaglikoglu, Gulsen
dc.contributor.authorYagmur, Sultan
dc.contributor.authorOrta, Erdem
dc.contributor.authorYilmaz, Selehattin
dc.date.accessioned2025-01-27T20:50:09Z
dc.date.available2025-01-27T20:50:09Z
dc.date.issued2011
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractAn electroanalytical method was developed for the direct quantitative determination of Acyclovir (Acy) in spiked human urine base on its oxidation behavior. The electrochemical oxidation and determination of Acy were easily carried out on ultra trace graphite electrode (UTGE) and glassy carbon electrode (GCE) using a variety of voltammetric techniques. The electrochemical measurements were carried out on these electrodes in various buffer solutions in the pH range of 3.66 to 9.08 by cyclic voltammetry (CV) and differential pulse voltammetry (DPV) techniques. The best results for the quantitative determination of Acy were obtained by DPV technique in 0.2 M acetate buffer (pH=4.66). In this acidic medium, one irreversible anodic peak was observed. The anodic peak current and peak potential depend on pH and scan rate were studied. The diffusion controlled nature of the peak was established. Acy was determined in the concentration range from 4x10(-6) to 7x10(-5) molL(-1) for UTGE and 2.0x10(-6) to 1.0x10(-4) molL(-1) for GCE by the applied electroanalytical procedure. Limit of detection (LOD) and limit of quantification (LOQ) were obtained as 1.0x10(-6) and 3.3x10(-6) molL(-1) on UTGE and 3.5x10(-7) and 1.2x10(-6) molL(-1) on GCE, respectively. Repeatability, precision and accuracy of the developed technique were checked by recovery studies in spiked urine.
dc.description.sponsorshipScientific and Technical Research Council of Turkey (TUBITAK) [TBAG-2173, 102T062]
dc.description.sponsorshipThe author gratefully acknowledges to the Scientific and Technical Research Council of Turkey (TUBITAK, Grant No: TBAG-2173; 102T062). The authors would also like to thank Ilsan Inc (stanbul, Tukey) for supplying pure Acy for developing proposed voltammetric technique.
dc.identifier.endpage135
dc.identifier.issn1573-4110
dc.identifier.issn1875-6727
dc.identifier.issue2
dc.identifier.scopus2-s2.0-79952757065
dc.identifier.scopusqualityQ2
dc.identifier.startpage130
dc.identifier.urihttps://hdl.handle.net/20.500.12428/25424
dc.identifier.volume7
dc.identifier.wosWOS:000289569200004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherBentham Science Publ Ltd
dc.relation.ispartofCurrent Analytical Chemistry
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectAcyclovir
dc.subjectDifferential pulse voltammetry
dc.subjectCyclic voltammetry
dc.subjectUltra trace graphite electrode
dc.subjectGlassy carbon electrode
dc.subjectHuman Urine
dc.titleVoltammetric Determination of Acyclovir in Human Urine Using Ultra Trace Graphite and Glassy Carbon Electrodes
dc.typeArticle

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