Prevention of intraocular pressure elevation with oleuropein rich diet in rabbits, during the general anaesthesia

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dc.authoridAltinisik, Hatice Betul/0000-0001-9273-0876
dc.contributor.authorSimsek, Tuncer
dc.contributor.authorAltinisik, Ugur
dc.contributor.authorErsan, Ismail
dc.contributor.authorSahin, Hasan
dc.contributor.authorAltinisik, Betul
dc.contributor.authorErbas, Mesut
dc.contributor.authorPala, Cigdem
dc.date.accessioned2025-01-27T20:44:00Z
dc.date.available2025-01-27T20:44:00Z
dc.date.issued2016
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground: Oleuropein is known to have anti-oxidant and anti-inflammatory effects. An important aim of anesthetic management in ocular surgery is to keep the intraocular pressure under control. Studies have researched a variety of prophylactic materials used to prevent increases in intraocular pressure. We aimed to research the effects of oleuropein on intraocular pressure (IOP) during general anaesthesia. Methods: Fourteen New Zealand rabbits were randomly divided into two groups of seven. The rabbits in Group O were given olive leaf extract (OLE) equivalent to a daily dose of 20 mg/kg oleuropein for 15 days. HPLC method used for oleuropein standardization. For anaesthesia induction 1 mg/kg rocuronium was given and after muscle relaxation all animals had a V-gel Rabbit inserted. Anesthetic maintenance was provided by 1 MAC isoflurane. Twenty minutes after rabbits were given 10 mg/kg ketamine, basal IOP values were measured. After the V-gel rabbit was inserted, in the 5th, 10th, 20th, 25th and 30th minutes measurements were repeated. Results: IOP data variation of OLE group was compared with control group and the measured levels were lower in Group O during the anaesthesia. IOP was 33.8 +/- 4 mmHg in Group C and 24.1 +/- 8 mmHg in Group O in 25th minute and the difference between the two groups was statistically significant at this time. Conclusion: We observed that consumption of prophylactic OLE had a reducing effect on IOP in the period before waking in anaesthesia. We believe it is necessary to investigate the effects of OLE on IOP in broad participation patient groups.
dc.identifier.doi10.1186/s40064-016-2402-3
dc.identifier.issn2193-1801
dc.identifier.pmid27386396
dc.identifier.scopus2-s2.0-84983085492
dc.identifier.scopusqualityN/A
dc.identifier.urihttps://doi.org/10.1186/s40064-016-2402-3
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24450
dc.identifier.volume5
dc.identifier.wosWOS:000378927800001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer International Publishing Ag
dc.relation.ispartofSpringerplus
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectOleuropein
dc.subjectRocuronium
dc.subjectGeneral anaesthesia
dc.subjectIntraocular pressure
dc.subjectRabbit
dc.titlePrevention of intraocular pressure elevation with oleuropein rich diet in rabbits, during the general anaesthesia
dc.typeArticle

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