Antiproliferative and Antioxidant Properties of Anthocyanin Rich Extracts from Blueberry and Blackcurrant Juice

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dc.authoridLeopold, Loredana Florina/0000-0002-8084-1998
dc.authoridSocaciu, Carmen/0000-0002-7352-5057
dc.authoridRUGINA, Dumitrita Olivia/0000-0003-4881-3273
dc.authoridDiaconeasa, Zorita/0000-0002-5325-3859
dc.contributor.authorDiaconeasa, Zorita
dc.contributor.authorLeopold, Loredana
dc.contributor.authorRugina, Dumitrita
dc.contributor.authorAyvaz, Huseyin
dc.contributor.authorSocaciu, Carmen
dc.date.accessioned2025-01-27T20:50:10Z
dc.date.available2025-01-27T20:50:10Z
dc.date.issued2015
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractThe present study was aimed at evaluating the antiproliferative potential of anthocyanin-rich fractions (ARFs) obtained from two commercially available juices (blueberry and blackcurrant juices) on three tumor cell lines; B16F10 (murine melanoma), A2780 (ovarian cancer) and HeLa (cervical cancer). Individual anthocyanin determination, identification and quantification were done using HPLC-MS. Antioxidant activity of the juices was determined through different mechanism methods such as DPPH and ORAC. For biological testing, the juices were purified through C-18 cartridges in order to obtain fractions rich in anthocyanins. The major anthocyanins identified were glycosylated cyanidin derivatives. The antiproliferative activity of the fractions was tested using the MTT assay. The antiproliferative potential of ARF was found to be associated with those bioactive molecules, anthocyanins due to their antioxidant potential. The results obtained indicated that both blueberry and blackcurrants are rich sources of antioxidants including anthocyanins and therefore these fruits are highly recommended for daily consumption to prevent numerous degenerative diseases.
dc.description.sponsorshipEuropean Social Fund, Human Resources Development Operational Programme [POSDRU/159/1.5/S/132765]; Romanian National Authority for Scientific Research, UEFISCDI [PN-II-RU-PD-2012-3-0283]
dc.description.sponsorshipThis paper was published under the frame of European Social Fund, Human Resources Development Operational Programme 2007-2013, project no. POSDRU/159/1.5/S/132765 and by a grant of the Romanian National Authority for Scientific Research, UEFISCDI, project number PN-II-RU-PD-2012-3-0283. We are also grateful to Dr. Manuela Banciu for providing the B16-F10 murine melanoma cell line and to Chiricuta Cancer Institute, Cluj-Napoca for providing HeLa and A2780 human cancer cell lines.
dc.identifier.doi10.3390/ijms16022352
dc.identifier.endpage2365
dc.identifier.issn1422-0067
dc.identifier.issue2
dc.identifier.pmid25622252
dc.identifier.scopus2-s2.0-84921885133
dc.identifier.scopusqualityQ1
dc.identifier.startpage2352
dc.identifier.urihttps://doi.org/10.3390/ijms16022352
dc.identifier.urihttps://hdl.handle.net/20.500.12428/25428
dc.identifier.volume16
dc.identifier.wosWOS:000350333600005
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofInternational Journal of Molecular Sciences
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectPerformance Liquid-Chromatography
dc.subjectCancer-Cell-Proliferation
dc.subjectChemical-Composition
dc.subjectCapacity
dc.subjectFruits
dc.subjectVaccinium
dc.subjectHealth
dc.subjectVegetables
dc.subjectPhenolics
dc.subjectCultivars
dc.titleAntiproliferative and Antioxidant Properties of Anthocyanin Rich Extracts from Blueberry and Blackcurrant Juice
dc.typeArticle

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