Thiol disulfide homeostasis in psychiatric disorders: A comprehensive review

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dc.authorid0000-0002-8514-0576en_US
dc.authorscopusid54792689200en_US
dc.authorwosidA-6386-2018en_US
dc.contributor.authorErgin Tuncay, Merve
dc.contributor.authorAtagün, Murat İlhan
dc.contributor.authorErel, Özcan
dc.date.accessioned2024-01-16T06:34:17Z
dc.date.available2024-01-16T06:34:17Z
dc.date.issued2023en_US
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractThiol-disulfide couple maintains an intracellular redox status. Dynamic thiol-disulfide homeostasis acts crucial parts in metabolic processes involving signal mechanisms, inflammation, antioxidant defense. Thiol-disulfide homeostasis have been implicated in numerous diseases. In this comprehensive review we identified the studies that examined the thiol-disulfide homeostasis in psychiatric disorders. Most cases demonstrated alterations in thiol-disulfide homeostasis and in most of them the thiol-disulfide balance tended to change direction to the disulfide side, that is, to the oxidative side. Currently, the fact that N-acetylcysteine, a thiol-containing compound, is of great interest as a new treatment approach in psychiatric disorders and the role of glutathione, the most abundant thiol, in the brain highlights the importance of evaluating the thiol-disulfide balance in psychiatric disorders.en_US
dc.identifier.citationErgin Tuncay, M., Atagün, M. I., & Erel, O. (2023). Thiol disulfide homeostasis in psychiatric disorders: A comprehensive review. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 123, 110719. https://doi.org/10.1016/j.pnpbp.2023.110719en_US
dc.identifier.doi10.1016/j.pnpbp.2023.110719
dc.identifier.issn0278-5846
dc.identifier.issn1878-4216
dc.identifier.pmid36634809
dc.identifier.scopus2-s2.0-85147457261
dc.identifier.urihttps://doi.org/10.1016/j.pnpbp.2023.110719
dc.identifier.urihttps://hdl.handle.net/20.500.12428/5242
dc.identifier.volume123en_US
dc.identifier.wosWOS:000994952400001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAtagün, Murat İlhan
dc.language.isoen
dc.publisherElsevier Inc.en_US
dc.relation.ispartofProgress in Neuro-Psychopharmacology and Biological Psychiatryen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntioxidantsen_US
dc.subjectNeuroinflammationen_US
dc.subjectOxidative stressen_US
dc.subjectPsychiatric disordersen_US
dc.subjectThiol-disulfide homeostasisen_US
dc.titleThiol disulfide homeostasis in psychiatric disorders: A comprehensive review
dc.typeReview Article

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