Effect of levosimendan on erythrocyte deformability during myocardial ischaemia-reperfusion injury

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dc.authoridArslan, Mustafa/0000-0003-4882-5063
dc.contributor.authorArslan, M.
dc.contributor.authorComu, F. M.
dc.contributor.authorAlkan, M.
dc.contributor.authorKiraz, H. A.
dc.contributor.authorKip, G.
dc.contributor.authorOzer, A.
dc.contributor.authorSivgin, V
dc.date.accessioned2025-01-27T20:24:47Z
dc.date.available2025-01-27T20:24:47Z
dc.date.issued2015
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractDiabetes mellitus (DM) is a chronic metabolic disorder accompanied by an increase in oxidative stress. Ischaemia-reperfusion (IR) injury is a cascade of events initiated by tissue ischaemia. The cellular damage produced by reperfusion leads to an active inflammatory response. Erythrocyte deformability and plasma viscosity are of crucial importance for the perfusion of tissues and organs. The aim of this study was to evaluate the effect of levosimendan on erythrocyte deformability during IR myocardial injury in diabetic rats. Methods: Twenty-four Wistar albino rats were included in the study after streptozocin (55 mg/kg) treatment for 4 weeks to observe the existence of diabetes. The animals were randomly assigned to one of four experimental groups. In Group C and DC (sham-control group), the coronary artery was not occluded or reperfused in the control rats. Myocardial IR was induced by ligation of the left anterior descending coronary artery for 30 min, followed by 2 h of reperfusion in the diabetes-IR (DIR) and diabetes-IR-levosimendan (DIRL) group. Deformability measurements were performed in erythrocyte suspensions containing Htc 5 % in a phosphate-buffered saline (PBS) buffer. Results: The deformability index was significantly increased in the diabetic rats. It was similar in Group DC and DIRL It was significantly increased in the DIR group compared to Group C, DIRL and DC. The relative resistance was increased in the IR models. Conclusion: Erythrocyte deformability was decreased in rats with diabetes and IR injury. This injury might lead to further problems in microcirculation. Levosimendan may be useful in enhancing the adverse effects of this type of injury (Fig. 2, Ref. 41). Text in PDF www.elis.sk.
dc.identifier.doi10.4149/BLL_2015_009
dc.identifier.endpage50
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.issue1
dc.identifier.pmid25666962
dc.identifier.scopus2-s2.0-84921341347
dc.identifier.scopusqualityQ2
dc.identifier.startpage47
dc.identifier.urihttps://doi.org/10.4149/BLL_2015_009
dc.identifier.urihttps://hdl.handle.net/20.500.12428/22344
dc.identifier.volume116
dc.identifier.wosWOS:000349275900009
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherComenius Univ
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listy
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjecterythrocyte deformability
dc.subjectmyocardial ischaemia reperfusion
dc.subjectexperimental diabetes
dc.subjectlevosimendan
dc.subjectrat
dc.titleEffect of levosimendan on erythrocyte deformability during myocardial ischaemia-reperfusion injury
dc.typeArticle

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