Nickel Chloride Hexahydrate Catalyzed Multicomponent Biginelli's Synthesis of 3,4-Dihydropyrimidin-2(1H)-Ones and Thiones

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dc.contributor.authorGulten, Sirin
dc.date.accessioned2025-01-27T20:48:04Z
dc.date.available2025-01-27T20:48:04Z
dc.date.issued2017
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractAn efficient protocol is reported for the one-pot three-component Bignelli synthesis of a series of 3,4-dihydropyrimidine-2(1H)-ones and thiones in good yields (66-90%) from the aldehydes (4-benzyloxybenzaldehyde, 5-bromovanilin, 4-formyl-1-cyclohexene, and trans-cinnamaldehyde), -keto esters (ethyl acetoacetate, allyl acetoacetate, and t-butyl acetoacetate), and urea/thiourea in ethanol, using nickel chloride hexahydrate as a catalyst.
dc.description.sponsorshipCanakkale Onsekiz Mart University Scientific Research Projects Coordination Department [BAP 2008/28]
dc.description.sponsorshipThe author thanks Canakkale Onsekiz Mart University Scientific Research Projects Coordination Department (BAP 2008/28) for financial support. The author also thank Canakkale Onsekiz Mart University, the Science and Technology Research and Application Center for recording NMR spectra and mass spectra, the NMR Analysis Laboratory of Hacettepe University and Gazi University for recording NMR spectra and Central Laboratory of Pharmacy, and Ankara University for the measurement of the mass spectra and elemental analysis.
dc.identifier.doi10.1002/jhet.2700
dc.identifier.endpage1260
dc.identifier.issn0022-152X
dc.identifier.issn1943-5193
dc.identifier.issue2
dc.identifier.scopus2-s2.0-84978199983
dc.identifier.scopusqualityQ2
dc.identifier.startpage1252
dc.identifier.urihttps://doi.org/10.1002/jhet.2700
dc.identifier.urihttps://hdl.handle.net/20.500.12428/25130
dc.identifier.volume54
dc.identifier.wosWOS:000397563000052
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Heterocyclic Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectOne-Pot Synthesis
dc.subjectSolvent-Free Conditions
dc.subjectSolid-Phase Synthesis
dc.subjectEfficient Synthesis
dc.subjectMagnesium Bromide
dc.subjectCondensation Reaction
dc.subject3-Component
dc.subjectDihydropyrimidinones
dc.subjectTetrahydropyrimidines
dc.titleNickel Chloride Hexahydrate Catalyzed Multicomponent Biginelli's Synthesis of 3,4-Dihydropyrimidin-2(1H)-Ones and Thiones
dc.typeArticle

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