Protective effect of glucagon-like peptide-2 in experimental corrosive esophagitis

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dc.authoridYildirim, Sule/0000-0002-1815-808X
dc.contributor.authorTekin, M.
dc.contributor.authorTopaloglu, N.
dc.contributor.authorKucuk, A.
dc.contributor.authorDeniz, M.
dc.contributor.authorYildirim, S.
dc.contributor.authorErdem, H.
dc.date.accessioned2025-01-27T20:44:19Z
dc.date.available2025-01-27T20:44:19Z
dc.date.issued2015
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractCorrosive esophageal injuries are one of the life-threatening morbidities leading to esophageal stricture and perforation affecting all age groups but especially children due to accidental ingestions in this age group. Glucagon-like peptide-2 (GLP-2) is an intestinal polypeptide with potent anti-inflammatory effects. Its effects are studied in various studies but not in corrosive esophagitis. We aimed to investigate whether it has protective effect in experimental corrosive esophagitis, in the absence of existing studies into possible links. Twenty-four Wistar-albino rats, weighing 220-240 g, were randomized into three groups (n=8 in each). First group is control, second one is sham operated, and the third one is treatment group. Median laparotomy was made in all groups. In sham and treatment groups, esophagus was loosened and suspended from 1cm proximal to the esophageal junction. The esophagus segment between suspenders was exposed to 0.1mL 5% NaOH for 10 seconds. In the treatment group, rats were given GLP-2 for 7 days intraperitoneally. After 7 days, all rats were sacrified and esophagi were totally removed. In the histopathologic examination, esophageal tissues were compared in terms of inflammation, muscularis mucosa injury, and collagen deposition of tunica muscularis. Histopathologic changes in the esophageal tissues of groups were compared. Histopathologic injury in the GLP-2 treated group was significantly less than sham group (P<0.05). There was statistically significant healing in the GLP-2 treatment group. It is concluded that GLP-2 has a preventive effect on inflammation and collagen accumulation in an experimental corrosive esophagitis. In the light of the information that initial lesions in the early phase are predictors of complications, GLP-2 is a promising agent that has an anti-inflammatory effect in caustic injuries.
dc.identifier.doi10.1111/dote.12195
dc.identifier.endpage261
dc.identifier.issn1120-8694
dc.identifier.issn1442-2050
dc.identifier.issue3
dc.identifier.pmid24641662
dc.identifier.scopus2-s2.0-84926422000
dc.identifier.scopusqualityQ2
dc.identifier.startpage258
dc.identifier.urihttps://doi.org/10.1111/dote.12195
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24536
dc.identifier.volume28
dc.identifier.wosWOS:000352501600010
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherOxford Univ Press Inc
dc.relation.ispartofDiseases of The Esophagus
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectcorrosive esophagitis
dc.subjectglucagon-like peptide-2
dc.subjectinflammation
dc.subjectrat
dc.titleProtective effect of glucagon-like peptide-2 in experimental corrosive esophagitis
dc.typeArticle

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