Does Omegaven have beneficial effects on a rat model of ovarian ischemia/reperfusion?

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dc.contributor.authorGungor, Ayse N. Cakir
dc.contributor.authorTurkon, Hakan
dc.contributor.authorAlbayrak, Aynur
dc.contributor.authorOvali, Mehmet
dc.contributor.authorIslimye, Mine
dc.contributor.authorGencer, Meryem
dc.contributor.authorHacivelioglu, Servet
dc.date.accessioned2025-01-27T20:41:04Z
dc.date.available2025-01-27T20:41:04Z
dc.date.issued2014
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective: The beneficial effects of omega-3 fatty acids on an intestinal ischemia/reperfusion (I/R) model was shown previously. Therefore, we aimed to examine the potential beneficial effects of parenteral omega-3 fatty acids, a safe and inexpensive product, on a rat model of ovarian I/R. Study design: A group of 39 rats was divided into six groups. Group 1 (Sham Group; n = 6) underwent two laparotomies with a 3-h interval and their ovaries were removed 3 h later. Group 2 (torsion detorsion Group; n = 7) had their ovaries torsioned clockwise and fixed at 7200; 3 h later a detorsion operation was done and after another 3 h, their ovaries were removed. Group 3 (n = 7) and Group 4 (n = 7) received the same treatment as Group 2; however, half an hour prior to detorsion, these rats received Omegaven at 1 mL/kg and 5 mL/kg, respectively. Group 5 (n = 6) and Group 6 (n = 6) received the same treatment as Group 1; however, half an hour prior to the second laparotomy, these rats received Omegaven at 1 mL/kg and 5 mL/kg, respectively. One ovary from each rat was evaluated histologically by hematoxylin and eosin (H&E) staining and the other ovary was homogenized and evaluated for total oxidant status (TOS), total antioxidant status (TAS) and oxidative stress index (OSI). Results: While we failed to show any significant relationship among groups in oxidative parameters, there was a significant worsening in the torsion detorsion group in histological evaluation. High Omegaven doses, but not low doses, improved tissue injury scores of torsioned and detorsioned ovaries to the levels observed in the control group. Conclusion: Omegaven improves the detrimental effects of ovarian I/R when used in sufficient doses. Its effects and dose adjustment on women with ovarian torsion must be investigated by further studies. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
dc.description.sponsorshipCanakkale Onsekiz Mart University Scientific Investigation Projects Coordination Unit [137]
dc.description.sponsorshipThis study was funded by Canakkale Onsekiz Mart University Scientific Investigation Projects Coordination Unit. Project Number: 137.
dc.identifier.doi10.1016/j.ejogrb.2014.08.001
dc.identifier.endpage245
dc.identifier.issn0301-2115
dc.identifier.issn1872-7654
dc.identifier.pmid25173683
dc.identifier.scopus2-s2.0-84907962225
dc.identifier.scopusqualityQ2
dc.identifier.startpage240
dc.identifier.urihttps://doi.org/10.1016/j.ejogrb.2014.08.001
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23997
dc.identifier.volume181
dc.identifier.wosWOS:000343952000043
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Bv
dc.relation.ispartofEuropean Journal of Obstetrics & Gynecology and Reproductive Biology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectOvarian torsion
dc.subjectIschemia/reperfusion injury
dc.subjectRat
dc.subjectOmega-3 fatty acids
dc.titleDoes Omegaven have beneficial effects on a rat model of ovarian ischemia/reperfusion?
dc.typeArticle

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