Combined Effect of Factor V Leiden, MTHFR, and Angiotensin-Converting Enzyme (Insertion/Deletion) Gene Mutations in Hypertensive Adult Individuals: A Population-Based Study from Sivas and Canakkale, Turkey

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dc.authoridSılan, Coşkun/0000-0002-8352-6571
dc.contributor.authorDemirel, Yeltekin
dc.contributor.authorDogan, Sezai
dc.contributor.authorUludağ, Ahmet
dc.contributor.authorSılan, Coşkun
dc.contributor.authorAtik, Sinem
dc.contributor.authorSılan, Fatma
dc.contributor.authorÖzdemir, Öztürk
dc.date.accessioned2025-01-27T20:11:45Z
dc.date.available2025-01-27T20:11:45Z
dc.date.issued2011
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground: Hypertension is one of the leading causes of mortality and morbidity in the world, which is influenced by environmental and genetic factors. The methylenetetrahydrofolate reductase (MTHFR) and angiotensin-converting enzymes (ACE) are possible candidate genes that may influence both body fatness and blood pressure (BP). The purpose of this study was to examine the carriage of gene combinations of the ACE (insertion/deletion [I/D]), MTHFR 677T and 1298C, and lipid profiles in patients with essential hypertension (EH) in Turkey. Methods: A total of 150 adult individuals (50 hypertensive, 50 first-degree relatives, and 50 healthy controls) from Sivas/Turkey with the same age and gender were assessed for body composition, lipid profiles, resting BP, and gene profiles. Additionally, 149 individuals (99 hypertensive, 50 controls) from Canakkale/Turkey had been investigated for ACE I/D polymorphism. Peripheral blood samples were genotyped using strip assay reverse-hybridization multiplex polymerase chain reaction tests for target genes. Results: Heterozygous mutation in FV Leiden was found to be higher in the hypertensive and first-degree relatives when compared with the control group (p < 0.05). Homozygous DD alleles of the ACE gene were also higher than the ACE I/D and control groups (p < 0.05). The high rates of cholesterol and low-density lipoprotein and low rates of high-density lipoprotein were found in patients with EH when compared with the control. Conclusion: Results show that ACE with DD alleles and mutated alleles of FV Leiden and MTHFR genes were significantly different between genotypes and have a combined effect on EH in Turkish population. Further studies are needed to investigate the genetics of obesity, EH, and BP phenotypes in the current adult population.
dc.identifier.doi10.1089/gtmb.2011.0044
dc.identifier.endpage791
dc.identifier.issn1945-0265
dc.identifier.issn1945-0257
dc.identifier.issue11
dc.identifier.pmid21699409
dc.identifier.scopus2-s2.0-81755184449
dc.identifier.scopusqualityQ3
dc.identifier.startpage785
dc.identifier.urihttps://doi.org/10.1089/gtmb.2011.0044
dc.identifier.urihttps://hdl.handle.net/20.500.12428/20708
dc.identifier.volume15
dc.identifier.wosWOS:000297263500008
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMary Ann Liebert, Inc
dc.relation.ispartofGenetic Testing and Molecular Biomarkers
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectAce I/D Polymorphism
dc.subjectIncident Hypertension
dc.subjectBlood-Pressure
dc.subjectRisk
dc.subjectVariant
dc.subjectHealth
dc.titleCombined Effect of Factor V Leiden, MTHFR, and Angiotensin-Converting Enzyme (Insertion/Deletion) Gene Mutations in Hypertensive Adult Individuals: A Population-Based Study from Sivas and Canakkale, Turkey
dc.typeArticle

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