An Unusual Case: The Comorbidity of Mood Disorder and 17-?-Hydroxylase Deficiency

Basit Öğe Kaydı
dc.contributor.authorTunc, Serhat
dc.contributor.authorYigiter, Sera
dc.contributor.authorAltinbas, Kursat
dc.contributor.authorKurt, Erhan
dc.contributor.authorOral, Timucin
dc.date.accessioned2025-01-27T20:16:39Z
dc.date.available2025-01-27T20:16:39Z
dc.date.issued2013
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstract17-alpha-hydroxylase enzyme has a crucial role in the steroid biosynthesis and, deficiency of this enzyme is an autosomal recessive monogenic disorder which is one of the two hypertensive form of congenital adrenal hyperplasia. It is characterized with the deficiency in glucocorticoid, adrenal androgen, and sex steroid synthesis with concomitant mineralocorticoid excess due to genetic defect in steroid biosynthesis. The relationship of hormone system physiology with psychiatric signs and syndromes are complex. Any problem in the hypothalamo-pituitary axis may cause psychiatric syndromes. On the other hand, many psychiatric disorders, such as mood-anxiety symptoms, depression, mania, psychosis, and delirium can be seen secondary to the treatment of hormone deficiency. We present the case of a male patient with pseudohermaphroditism who has been followed and treated in Rasit Tahsin Mood Clinic with the diagnosis of mood disorder not otherwise specified and was diagnosed with 46,XY karyotype and 17-alpha-hydroxylase deficiency after referring to a hospital with delayed puberty. Considering the medical literature, 17-alpha-hydroxylase deficiency has been evaluated from the aspects of gender-related behavioral disorders, psychological developmental and anxiety disorders. To the best of our knowledge, in the medical literature, this is the first case of 17-alpha-hydroxylase deficiency associated with mood disorder. Here, the relationship between mood disorders and hypothalamo-pituitary axis is discussed in the light of the literature.
dc.identifier.doi10.4274/npa.y6400
dc.identifier.endpage282
dc.identifier.issn1300-0667
dc.identifier.issue3
dc.identifier.pmid28360556
dc.identifier.scopus2-s2.0-84884539253
dc.identifier.scopusqualityQ3
dc.identifier.startpage279
dc.identifier.urihttps://doi.org/10.4274/npa.y6400
dc.identifier.urihttps://hdl.handle.net/20.500.12428/21333
dc.identifier.volume50
dc.identifier.wosWOS:000325969200015
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isotr
dc.publisherAves
dc.relation.ispartofNoropsikiyatri Arsivi-Archives of Neuropsychiatry
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subject17-alpha-hydroxylase deficiency
dc.subjectpseudohermaphroditism
dc.subjectcongenital adrenal hyperplasia
dc.subjectmood disorder
dc.titleAn Unusual Case: The Comorbidity of Mood Disorder and 17-?-Hydroxylase Deficiency
dc.title.alternativeÇok nadir görülen bir olgu: 17-? hidroksilaz eksikli?i ve duygudurum bozuklu?u birlikteli?i
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu