The Quantitative Detection of Phenylephrine in Pharmaceutical Preparations and Spiked Human Urine by Voltammetry

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dc.authoridSaglikoglu, Gulsen/0000-0002-3407-9787
dc.contributor.authorYagmur, S.
dc.contributor.authorTure, M.
dc.contributor.authorSaglikoglu, G.
dc.contributor.authorSadikoglu, M.
dc.contributor.authorYilmaz, S.
dc.date.accessioned2025-01-27T20:43:35Z
dc.date.available2025-01-27T20:43:35Z
dc.date.issued2018
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractA voltammetric method was used for the quantitative detection of phenylephrine in pharmaceutical preparations and spiked human urine. The electrochemical measurements were carried out in various buffer solutions in the pH range from 0.51 to 12.00 on ultra-trace graphite electrode (UTGE) by cyclic voltammetry (CV) and differential pulse voltammetry (DPV) techniques. The dependence of pH on the oxidation peak current and peak potential was investigated. Britton-Robinson buffer (pH 8.02) was selected for analytical purposes. The peak was established to be diffusion controlled nature of electrode. A linear calibration curve for DPV analysis was constructed in the phenylephrine concentration range from 8 x 10(-6) to 1 x 10(-4) M. Limits of detection (LOD) and quantification (LOQ) were obtained as 2.07 x 10(-7) M and 6.91 x 10(-6) M respectively. The repeatability, accuracy and precision of the developed technique were checked in spiked urine and pharmaceutical preparations.
dc.identifier.doi10.1134/S1023193518100063
dc.identifier.endpage746
dc.identifier.issn1023-1935
dc.identifier.issn1608-3342
dc.identifier.issue10
dc.identifier.scopus2-s2.0-85056892796
dc.identifier.scopusqualityQ4
dc.identifier.startpage741
dc.identifier.urihttps://doi.org/10.1134/S1023193518100063
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24282
dc.identifier.volume54
dc.identifier.wosWOS:000450579800001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherPleiades Publishing Inc
dc.relation.ispartofRussian Journal of Electrochemistry
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectphenylephrine
dc.subjectdetection
dc.subjectvoltammetry
dc.subjectpharmaceutical preparations
dc.subjecthuman urine
dc.titleThe Quantitative Detection of Phenylephrine in Pharmaceutical Preparations and Spiked Human Urine by Voltammetry
dc.typeArticle

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