The hepatoprotective effect of Aloe vera on ischemia-reperfusion injury in rats

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dc.contributor.authorSehitoglu, Muserref Hilal
dc.contributor.authorKaraboga, Ihsan
dc.contributor.authorKiraz, Asli
dc.contributor.authorKiraz, Hasan Ali
dc.date.accessioned2025-01-27T20:49:43Z
dc.date.available2025-01-27T20:49:43Z
dc.date.issued2019
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractOBJECTIVE: Aloe vera is known for its antioxidant properties. In this experimental study, we aimed to investigate the efficacy of Aloe vera in ischemia-reperfusion (I/R) liver injury in rats. METHODS: Male Wistar Albino rats were divided into three groups, where the sham group (n=7) underwent no medication or surgical procedures, the I/R group (n=7) was the control group that received 45 minutes of applied abdominal aorta ischemia and rats were sacrificed 24 hours after reperfusion, and the I/R+AV group (n=7) was the treatment group that was given Aloe vera (30 mg/kg) every day followed by gastric lavage for a month before applying ischemia and performing sacrifice as in the previous group. Before sacrifice, all the liver tissues were removed. Tissues were examined for histopathological investigation, iNOS immunoreactivity and tissue biochemistry, malondialdehyde (MDA), catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) activities. RESULTS: The SOD, CAT, and GSH-Px levels of the I/R+AV group were not significantly different from the sham group (p>0.05) but were significantly higher when compared to the I/R group. MDA levels of liver tissues were significantly lower (p<0.05) in the I/R+AV group as compared to the I/R group. Disrupted hepatic cords, sinusoidal dilatation, hemorrhage, cytoplasmic vacuolization of hepatocytes, and intensive iNOS immunoreactivity were detected in the I/R group. Decreased histopathological change score and iNOS immunoreactivity score were noticed in the I/R+AV group as compared to the I/R group. CONCLUSION: It was found that Aloe vera showed a hepatoprotective effect against I/R injury. Further research is required to determine the effective dose, administration method, and effects of Aloe vera for liver transplantation.
dc.identifier.doi10.14744/nci.2018.82957
dc.identifier.endpage209
dc.identifier.issn2148-4902
dc.identifier.issue3
dc.identifier.pmid31650105
dc.identifier.startpage203
dc.identifier.trdizinid337880
dc.identifier.urihttps://doi.org/10.14744/nci.2018.82957
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/337880
dc.identifier.urihttps://hdl.handle.net/20.500.12428/25288
dc.identifier.volume6
dc.identifier.wosWOS:000486393500001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherKare Publ
dc.relation.ispartofNorthern Clinics of Istanbul
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectAloe vera
dc.subjecthepatoprotective
dc.subjectischemia-reperfusion
dc.subjectrat
dc.titleThe hepatoprotective effect of Aloe vera on ischemia-reperfusion injury in rats
dc.typeArticle

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