Investigation of Blood Betatrophin Levels in Obese Children with Non-Alcoholic Fatty Liver Disease

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dc.authoridAylanc, Hakan/0000-0002-8907-3809
dc.contributor.authorBattal, Fatih
dc.contributor.authorTurkon, Hakan
dc.contributor.authorAylanc, Nilufer
dc.contributor.authorAylanc, Hakan
dc.contributor.authorYildirim, Sule
dc.contributor.authorKaymaz, Nazan
dc.contributor.authorUysal, Sema
dc.date.accessioned2025-01-27T20:39:07Z
dc.date.available2025-01-27T20:39:07Z
dc.date.issued2018
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractPurpose: The prevalence of obesity has significantly increased among children and adolescents worldwide and is becoming an important health care problem in parallel with the increased prevalence of obesity pediatric non-alcoholic fatty liver disease. Betatrophin is a newly define hormone that is commonly secreted by liver and plays role in glucose tolerance. This study aimed to investigate the relationship between serum betatrophin levels and non-alcoholic fatty liver disease in obese children. Methods: The study included 40 obese children with a body mass index (BMI) above 95th centile, and 35 non-obese subjects with a BMI 3-85th centile, whose age and gender were similar to those of the patient group. For the evaluation of metabolic parameters fasting serum glucose, insulin, alanine aminotransferase, aspartate aminotransferase, lipid profile and serum betatrophin levels were measured. Total cholesterol: high-density lipoprotein cholesterol and low-density lipoprotein cholesterol: high-density lipoprotein cholesterol ratios were calculated as atherogenic indices. Results: Serum betatrophin levels of the obese subjects were similar to that of non-obese subjects (p=0.90). Betatrophin levels were not correlated with the metabolic parameters. Conclusion: In the present study, levels of betatrophin are not different between obese and insulin resistant children and non-obese subjects, and they are not correlated with atherogenic indices. To elucidate the exact role of betatrophin in obesity, further studies are required to identify the betatrophin receptor and/or other possible cofactors.
dc.identifier.doi10.5223/pghn.2018.21.2.111
dc.identifier.endpage117
dc.identifier.issn2234-8646
dc.identifier.issn2234-8840
dc.identifier.issue2
dc.identifier.pmid29713608
dc.identifier.scopus2-s2.0-85045711288
dc.identifier.scopusqualityQ2
dc.identifier.startpage111
dc.identifier.urihttps://doi.org/10.5223/pghn.2018.21.2.111
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23865
dc.identifier.volume21
dc.identifier.wosWOS:000430535500005
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherKorean Soc Pediatric Gastroenterology & Nutrition
dc.relation.ispartofPediatric Gastroenterology Hepatology & Nutrition
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectBetatrophin
dc.subjectChild
dc.subjectObesity
dc.subjectLiver
dc.titleInvestigation of Blood Betatrophin Levels in Obese Children with Non-Alcoholic Fatty Liver Disease
dc.typeArticle

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