Lactoferrin as a Versatile Agent in Nanoparticle Applications: From Therapeutics to Agriculture

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dc.contributor.authorAkdasci, Emir
dc.contributor.authorEker, Furkan
dc.contributor.authorDuman, Hatice
dc.contributor.authorSingh, Priyanka
dc.contributor.authorBechelany, Mikhael
dc.contributor.authorKarav, Sercan
dc.date.accessioned2025-01-27T20:14:14Z
dc.date.available2025-01-27T20:14:14Z
dc.date.issued2024
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractNanoparticles (NPs) have emerged as a potent choice for various applications, from drug delivery to agricultural studies, serving as an alternative and promising methodology for future advancements. They have been widely explored in delivery systems, demonstrating immense promise and high efficiency for the delivery of numerous biomolecules such as proteins and anticancer agents, either solely or modified with other compounds to enhance their capabilities. In addition, the utilization of NPs extends to antimicrobial studies, where they are used to develop novel antibacterial, antifungal, and antiviral formulations with advanced characteristics. Lactoferrin (Lf) is a glycoprotein recognized for its significant multifunctional properties, such as antimicrobial, antioxidant, anti-inflammatory, anticancer, and neuroprotective effects. Its activity has a broad distribution in the human body, with Lf receptors present in multiple regions. Current research shows that Lf is utilized in NP technology as a surface material, encapsulated biomolecule, and even as an NP itself. Due to the abundance of Lf receptors in various regions, Lf can be employed as a surface material in NPs for targeted delivery strategies, particularly in crossing the BBB and targeting specific cancers. Furthermore, Lf can be synthesized in an NP structure, positioning it as a strong candidate in future NP-related applications. In this article, we explore the highlighted and underexplored areas of Lf applications in NPs research.
dc.identifier.doi10.3390/nano14242018
dc.identifier.issn2079-4991
dc.identifier.issue24
dc.identifier.pmid39728554
dc.identifier.scopus2-s2.0-85213426388
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/nano14242018
dc.identifier.urihttps://hdl.handle.net/20.500.12428/21011
dc.identifier.volume14
dc.identifier.wosWOS:001384417500001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofNanomaterials
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectlactoferrin
dc.subjectnanoparticles
dc.subjectantimicrobial activity
dc.subjectdrug delivery
dc.subjectanticancer
dc.subjectagriculture
dc.subjectneuroprotection
dc.subjecttoxicity
dc.titleLactoferrin as a Versatile Agent in Nanoparticle Applications: From Therapeutics to Agriculture
dc.typeReview Article

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