Sensitive Detection of Ornidazole by Poly(p-Aminobenzene Sulfonic Acid)-Modified Glassy Carbon Electrode

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dc.authoridSaglikoglu, Gulsen/0000-0002-3407-9787
dc.authoridYilmaz, Selehattin/0000-0003-4607-3523
dc.contributor.authorSaglikoglu, Gulsen
dc.contributor.authorYilmaz, Selehattin
dc.date.accessioned2025-01-27T21:01:36Z
dc.date.available2025-01-27T21:01:36Z
dc.date.issued2014
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractOrnidazole is an antibacterial drug active compound. A glassy carbon electrode (GCE) was modified with an electropolymerized film of p-aminobenzene sulfonic acid (p-ABSA) in pH 7.0 phosphate buffer solution (PBS). The electrochemical properties of the polymer film were studied using cyclic voltammetry (CV) and different pulse voltammetry (DPV) techniques. The polymer film-modified electrode was used to electrochemically detect ornidazole. The polymer film showed excellent electrocatalytic activity for the reduction of ornidazole. The cathodic peak potential value of the ornidazole at the p-ABSA modified glasy carbon electrode was -513 mV obtained by DPV. A linear calibration curve for DPV analysis was constructed in the ornidazole concentration range 8x10(-7) -5x10(-5) M. Limit of detection (LOD) and limit of quantification (LOQ) were 1.00x10(-7) and 3.32x10(-7) M respectively. The DPV technique proposed was successfully applied to the detection of ornidazole in tablet dosage forms. Precision and accuracy of the developed technique were checked by recovery studies. The proposed method exhibits good recovery and reproducibility. The mechanisms of electropolymerization of p-ABSA and reduction of ornidazole at p-ABSA-modified GCE are also suggested.
dc.description.sponsorshipCanakkale Onsekiz Mart University Grants Commission [2013/87]
dc.description.sponsorshipWe would like to thank Abdi Ibrahim (Istanbul, Turkey) for supplying pure ornidazole and its ornisid tablet dosage forms for developing the proposed voltammetric techniques. The authors thank Canakkale Onsekiz Mart University Grants Commission for a research grant (Project Number: 2013/87). Authors also thank Assoc. Prof. Dr. Mustafa YILDIZ (Department of Chemistry, Faculty of Arts & Sciences, Canakkale Onsekiz Mart University) for scientific discussions on mechanisms of electropolymerization and reduction of ornidazole.
dc.identifier.endpage464
dc.identifier.issn1573-4110
dc.identifier.issn1875-6727
dc.identifier.issue4
dc.identifier.scopus2-s2.0-84904739309
dc.identifier.scopusqualityQ2
dc.identifier.startpage457
dc.identifier.urihttps://hdl.handle.net/20.500.12428/27119
dc.identifier.volume10
dc.identifier.wosWOS:000338710900002
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherBentham Science Publ Ltd
dc.relation.ispartofCurrent Analytical Chemistry
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectOrnidazole
dc.subjectpharmaceutical formulation
dc.subjectp-Aminobenzene sulfonic acid
dc.subjectmodified-glassy carbon electrode
dc.subjectelectropolymerization
dc.subjectelectrocatalysis
dc.subjectdetermination
dc.subjectvoltammetry
dc.titleSensitive Detection of Ornidazole by Poly(p-Aminobenzene Sulfonic Acid)-Modified Glassy Carbon Electrode
dc.typeArticle

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