Exploring gastrointestinal manifestations in childhood onset systemic lupus erythematosus - Insights from a multicenter study

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dc.authoridYüksel, Selçuk / 0000-0001-9415-1640
dc.contributor.authorSönmez, Hafize Emine
dc.contributor.authorBatu, Ezgi Deniz
dc.contributor.authorİşgüder, Rana
dc.contributor.authorŞahin, Nihal
dc.contributor.authorAliyev, Emil
dc.contributor.authorAslan, Esma
dc.contributor.authorÇoban, Sümeyra
dc.contributor.authorYüksel, Selçuk
dc.date.accessioned2025-01-27T20:20:51Z
dc.date.available2025-01-27T20:20:51Z
dc.date.issued2024
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective Systemic lupus erythematosus (SLE) constitutes an autoimmune disorder with potential involvement of the gastrointestinal system (GIS). Our objective was to assess the gastrointestinal (GI) manifestations in patients diagnosed with childhood onset SLE.Methods The study cohort consisted of 123 patients with childhood onset-SLE and GIS involvement from 16 referral departments of pediatric rheumatology. All participants met the Systemic Lupus International Collaborating Clinics criteria.Results Out of 123 patients, 78 (63.4%) exhibited GIS involvement at the initial SLE diagnosis, whereas the remaining 45 (36.6%) developed GI symptoms after a median duration of 12 (3-140) months. Eighty-two (66.7%) individuals experienced symptoms related to the GI tract, whereas the remaining patients received a diagnosis of GI involvement through laboratory assessments. The predominant initial GIS involvement symptom was abdominal pain, observed in 77 (62.6%) patients, followed by elevated hepatic transaminases in 70 (56.9%), hepatomegaly in 40 (32.5%), diarrhea in 26 (21.1%), and jaundice in 11 (8.9%) patients. The GIS involvement was associated with SLE in 82 (78.6%), while it resulted from drug-related adverse events in 35 (28.5%) patients or comorbidities in 6 (0.5%) patients.Conclusion GIS involvement should be considered in all childhood onset-SLE patients, especially in the presence of suggestive symptoms or elevated hepatic transaminases. It is also crucial to consider SLE in the differential diagnosis of GIS manifestations in children. Apart from GIS involvement directly associated with SLE, adverse events of drugs should be kept in mind.
dc.identifier.doi10.1177/09612033241279071
dc.identifier.endpage1364
dc.identifier.issn0961-2033
dc.identifier.issn1477-0962
dc.identifier.issue12
dc.identifier.pmid39186467
dc.identifier.scopus2-s2.0-85202175422
dc.identifier.scopusqualityQ2
dc.identifier.startpage1358
dc.identifier.urihttps://doi.org/10.1177/09612033241279071
dc.identifier.urihttps://hdl.handle.net/20.500.12428/21832
dc.identifier.volume33
dc.identifier.wosWOS:001298497700001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSage Publications Ltd
dc.relation.ispartofLupus
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectSystemic lupus erythematosus
dc.subjectgastrointestinal system
dc.subjectchild
dc.subjectautoimmune hepatitis
dc.titleExploring gastrointestinal manifestations in childhood onset systemic lupus erythematosus - Insights from a multicenter study
dc.typeArticle

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