Relationship Between Response to Colchicine Treatment and MDR1 Polymorphism in Familial Mediterranean Fever Patients

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dc.authoridSılan, Coşkun/0000-0002-8352-6571
dc.contributor.authorUludağ, Ahmet
dc.contributor.authorSılan, Coşkun
dc.contributor.authorAtik, Sinem
dc.contributor.authorAkurut, Cisem
dc.contributor.authorUludag, Aysegul
dc.contributor.authorSılan, Fatma
dc.contributor.authorÖzdemir, Öztürk
dc.date.accessioned2025-01-27T20:44:08Z
dc.date.available2025-01-27T20:44:08Z
dc.date.issued2014
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractAim: Investigate the relationship between MDR1 C3435T polymorphism and colchicine response in Familial Mediterranean fever (FMF) patients. Materials and Methods: Patients (n=50) who received colchicine regularly, were willing to participate in the study, and attended control visits were included in the study. MDR1 C3435T genotype was defined by the real-time polymerase chain reaction method. Patients were divided into three groups. Patients, who recovered from episodes with standard colchicine treatment, and had no attack in the last 1 year were accepted as complete; patients whose episode number and intensity were decreased with the ongoing standard treatment as partial; and patients whose episodes were not decreased despite the standard treatment as nonresponders. Results:MDR1 C and T allele frequencies of FMF patients with colchicine responses of complete, partial, and nonresponders were C=0.75 and T=0.25; C=0.56 and T=0.44; and C=0.50 and T=0.50, respectively. When complete responding patients were compared with the partial responding patients, subjects with CT genotype had 6.18 times more increased risk than with CC genotype (OR=6.18; p=0.015). Poor response risk of subjects with the T allele was increased 2.45 times more when compared with the C allele (p=0.03). Conclusion:MDR1 gene C3435T polymorphism enacts an important role on colchicine response in FMF; good response to colchicine treatment was related to the C allele, whereas poor response was related to the T allele in FMF.
dc.identifier.doi10.1089/gtmb.2013.0293
dc.identifier.endpage76
dc.identifier.issn1945-0265
dc.identifier.issn1945-0257
dc.identifier.issue2
dc.identifier.pmid24180297
dc.identifier.scopus2-s2.0-84893815609
dc.identifier.scopusqualityQ3
dc.identifier.startpage73
dc.identifier.urihttps://doi.org/10.1089/gtmb.2013.0293
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24487
dc.identifier.volume18
dc.identifier.wosWOS:000331388300002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMary Ann Liebert, Inc
dc.relation.ispartofGenetic Testing and Molecular Biomarkers
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectMediated Multidrug-Resistance
dc.subjectGenetic Polymorphisms
dc.subjectDrug Transporters
dc.subjectExpression
dc.subjectProtein
dc.titleRelationship Between Response to Colchicine Treatment and MDR1 Polymorphism in Familial Mediterranean Fever Patients
dc.typeArticle

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