Cognitive performance, psychiatric comorbidities, and quality of life in pediatric patients with juvenile idiopathic arthritis: a comparative analysis with healthy controls

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dc.authoridYüksel, Selçuk / 0000-0001-9415-1640
dc.contributor.authorTezer, Damla
dc.contributor.authorKabukçu Başay, Burge
dc.contributor.authorBaşay, Ömer
dc.contributor.authorOtar Yener, Gülçin
dc.contributor.authorYüksel, Selçuk
dc.date.accessioned2025-01-27T20:25:04Z
dc.date.available2025-01-27T20:25:04Z
dc.date.issued2024
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractThis study aimed to assess the extent of cognitive impairment in children and adolescents with Juvenile Idiopathic Arthritis (JIA). While cognitive deficits are recognized in other systemic rheumatic diseases, exploration within the pediatric JIA population remains limited. The investigation utilized a comprehensive approach to examine neuropsychological test performance. A cohort of 160 participants (79 JIA, 81 healthy controls aged 8-17) underwent evaluations using the Pediatric Quality of Life Inventory (PedsQL), Schedule for Affective Disorders and Schizophrenia for School Age Children-Present and Lifetime Version (K-SADS-PL), and the computerized neurocognitive test battery Central Nervous System Vital Signs (CNSVS). Children with JIA exhibited statistically significant cognitive deficits across various parameters (p < .05). This was associated with an increased prevalence of lifelong psychiatric illnesses and diminished overall quality of life compared to healthy counterparts (p < .05). Analysis highlighted that specific JIA subtypes, excluding Oligoarthritis, significantly elevated the risk of neurocognitive impairments, emphasizing the impact on various cognitive outcomes (OR range: 3.1-5.1, 95% CI: 1.163-19.980). Additionally, the active disease stage was identified as a specific risk factor, amplifying the likelihood of low executive functions by 4.3 times (OR: 4.363, 95% CI: 1.095-17.378). This study underscores the critical importance of recognizing and addressing neurocognitive impairments in children with JIA. Specific attention to disease subtypes and activity levels is crucial, with the potential for targeted interventions to enhance overall cognitive well-being and quality of life in this vulnerable population.
dc.identifier.doi10.1080/09297049.2024.2426272
dc.identifier.issn0929-7049
dc.identifier.issn1744-4136
dc.identifier.pmid39569588
dc.identifier.scopus2-s2.0-85209991496
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1080/09297049.2024.2426272
dc.identifier.urihttps://hdl.handle.net/20.500.12428/22424
dc.identifier.wosWOS:001361570300001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherRoutledge Journals, Taylor & Francis Ltd
dc.relation.ispartofChild Neuropsychology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectJuvenile idiopathic arthritis
dc.subjectneuropsychological functioning
dc.subjectcognitive impairment
dc.subjectquality of life
dc.subjectpsychiatric comorbidity
dc.titleCognitive performance, psychiatric comorbidities, and quality of life in pediatric patients with juvenile idiopathic arthritis: a comparative analysis with healthy controls
dc.typeArticle

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