Demographic, clinical and laboratory characteristics of extrapulmonary tuberculosis: Eight-year results of a multicenter retrospective study in Turkey

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dc.authoridAlkan, Sevil / 0000-0003-1944-2477
dc.contributor.authorÇelik, Mehmet
dc.contributor.authorGürbüz, Esra
dc.contributor.authorÇiçek, Yeliz
dc.contributor.authorBüyüktuna, Seyit Ali
dc.contributor.authorGündağ, Ömür
dc.contributor.authorGülderen Kuşçu, Evrim
dc.contributor.authorMermutluoğlu, Çiğdem
dc.contributor.authorAlkan, Sevil
dc.date.accessioned2025-05-29T02:57:39Z
dc.date.available2025-05-29T02:57:39Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractExtrapulmonary tuberculosis (EPTB) is an important public health problem due to its diverse clinical presentations, diagnostic complexities, and significant impact on patient outcomes and public health. Our study aimed to understand the sociodemographic, clinical, and laboratory characteristics as well as diagnostic and treatment modalities of adult patients with EPTB. This is a multicentric retrospective study that covers patients with EPTB cases followed up from January 2015 to December 2022 among tuberculosis (TB) dispensaries and Infectious Diseases and Clinical Microbiology clinics of 15 hospitals located in various regions of Turkey. The study included 64.6% women with a mean age of 44 years and a mortality rate of 3.5% within 1 year of diagnosis. Initial constitutional symptoms were predominantly fatigue (57%) and anorexia (53.7%). The most commonly affected sites were the lymph nodes (49.1%) and pleura (9.7%). The lumbar region was particularly involved in cases with spinal TB. Diagnostic findings included acid-fast bacilli positivity in 27.5% of cases, tuberculosis polymerase chain reaction positivity in 41%, elevated adenosine deaminase levels in 91.2% (especially in pleural and peritoneal fluids), and mycobacterial culture positivity in 40.9%. Pathology slides showed granulomatous inflammation in 97.7%. Increased C-reactive protein (CRP) levels correlated with the number of organs affected. Anti-TB treatment-related hepatotoxicity was detected in 8.9% of patients. In this study, it is important to note that the lumbar region is predominantly affected with involvement in spinal region. CRP level was consistent with the number of organ involvements and was one of the most critical results of this study.
dc.identifier.doi10.1177/10815589241299367
dc.identifier.endpage217
dc.identifier.issn1081-5589
dc.identifier.issn1708-8267
dc.identifier.issue2
dc.identifier.pmid39508290
dc.identifier.scopus2-s2.0-85218494042
dc.identifier.scopusqualityQ2
dc.identifier.startpage206
dc.identifier.urihttps://doi.org/10.1177/10815589241299367
dc.identifier.urihttps://hdl.handle.net/20.500.12428/30121
dc.identifier.volume73
dc.identifier.wosWOS:001397577400001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSage Publications Ltd
dc.relation.ispartofJournal of Investigative Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250529
dc.subjectExtrapulmonary
dc.subjecttuberculosis
dc.subjectC-reactive protein
dc.subjectadenosine deaminase
dc.subjectlymph node
dc.subjectcervical
dc.titleDemographic, clinical and laboratory characteristics of extrapulmonary tuberculosis: Eight-year results of a multicenter retrospective study in Turkey
dc.typeArticle

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