A facile one-pot synthesis of microgels and nanogels of laminarin for biomedical applications
Yükleniyor...
Tarih
2021
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Academic Press Inc.
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Hypothesis: Laminarin (LAM) as a nontoxic, biodegradable, and biocompatible marine polysaccharide, has been reported for its ingenious bioactivities such as antioxidant, antitumor antiapoptotic anti-inflammatory, immunomodulatory and dietary fiber activities, and distinct physicochemical structure possess a remarkably promising potential in biomaterial science. Synthesis of LAM-based microgels and bulk hydrogels have been reported in two stages: modification of LAM polysaccharide with polymerizable functional groups and subsequent crosslinking reaction. Therefore, here an easier and more effortless methods to prepare poly(laminarin) (p(LAM)) particles were tackled. Experimental: A direct and facile single step fabrication of micro/nanogels of p(LAM) for the first time by means of reverse micelle microemulsion system were illustrated. Preparation of p(LAM) particles were achieved by the well-known Oxa-Michael addition reaction mechanism using divinyl sulfone as the crosslinker. Findings: P(LAM) particles in 0.3–10 µm size range in spherical morphologies were prepared with 93 ± 7% yield and functionalized with chlorosulfonic acid (CSA) demonstrating their chemical modifiability for variety of agents e.g., targeting ligands. The bare and modified p(LAM) particles showed excellent blood compatibility with hemolytic indices of <1% and blood clotting indices higher than 90%. The reported p(LAM) particles hold great promise as natural alternative surrogates in biomedical applications including drug delivery.
Açıklama
Anahtar Kelimeler
Blood compatible, Laminarin, Laminarin microgel and nanogel, Seaweed polysaccharide
Kaynak
Journal of Colloid and Interface Science
WoS Q Değeri
Q1
Scopus Q Değeri
Cilt
588
Sayı
Künye
Can, M., & Şahiner, N. (2021). A facile one-pot synthesis of microgels and nanogels of laminarin for biomedical applications. Journal of Colloid and Interface Science, 588, 40–49. https://doi.org/10.1016/j.jcis.2020.12.053
