Panax ginseng protects against copper sulfate-induced kidney toxicity in rats

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dc.contributor.authorGules, Ozay
dc.contributor.authorYildiz, Mustafa
dc.contributor.authorBoyacioglu, Murat
dc.contributor.authorSevimli, Alper
dc.contributor.authorDayi, Belma
dc.date.accessioned2026-02-03T11:59:45Z
dc.date.available2026-02-03T11:59:45Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective:To assess the protective effects of Panax ginseng (PG) against copper sulfate (CuSO4)-induced kidney toxicity in rats.Methods:The rats were randomly allocated into four groups: control, CuSO4, PG, and PG+CuSO4. The experiment continued for 14 days, during which CuSO4 was provided at a dosage of 100 mg/kg body weight per day and PG at 300 mg/kg body weight by oral gavage per day. Upon completion of the experiment, kidney sections were used for histological and histomorphometric analyses. The histochemical method was applied to ascertain the density of the glomerular mesangial matrix. The expressions of vascular endothelial growth factor (VEGF) and caspase-3 were examined using immunohistochemistry. The levels of malondialdehyde and glutathione, along with the activity of superoxide dismutase and catalase in the kidney, were measured.Results:PG treatment exhibited a marked protective effect against CuSO4-induced renal damage, as evidenced by improved histopathological lesions, significantly reduced glomerular mesangial matrix density, VEGF in distal tubules, caspase-3 expression, and malondialdehyde levels in renal tissue, as well as enhanced superoxide dismutase and catalase activities.Conclusions:PG treatment ameliorates CuSO4-induced kidney injury in rats. Further studies are warranted to verify its efficacy and elucidate the underlying mechanism of its nephroprotective action.
dc.identifier.doi10.4103/apjtb.apjtb_176_25
dc.identifier.issn2221-1691
dc.identifier.issn2588-9222
dc.identifier.issue11
dc.identifier.scopus2-s2.0-105021427021
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.4103/apjtb.apjtb_176_25
dc.identifier.urihttps://hdl.handle.net/20.500.12428/34407
dc.identifier.volume15
dc.identifier.wosWOS:001611412900001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWolters Kluwer Medknow Publications
dc.relation.ispartofAsian Pacific Journal of Tropical Biomedicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20260130
dc.subjectCopper sulfate
dc.subjectKidney
dc.subjectPanax ginseng
dc.subjectVEGF
dc.subjectAntioxidant
dc.titlePanax ginseng protects against copper sulfate-induced kidney toxicity in rats
dc.typeArticle

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