The Functional Role of Polyphenols Across the Human Lifespan

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dc.authorid0000-0003-4056-1673
dc.authorid0000-0002-2913-2846
dc.contributor.authorKoca, Bekir Enes
dc.contributor.authorSaritas, Sumeyye
dc.contributor.authorBechelany, Mikhael
dc.contributor.authorKarav, Sercan
dc.date.accessioned2026-02-03T11:59:59Z
dc.date.available2026-02-03T11:59:59Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractPolyphenols are bioactive molecules that occur naturally in plants and exhibit a diverse array of properties, including antioxidant, anti-inflammatory, and anti-obesity effects, all of which have been supported by numerous studies. They are categorized into four main groups: flavonoids, phenolic acids, stilbenes, and lignans. Polyphenols demonstrate a wide range of health-promoting effects throughout human life, from the womb to old age. They can exert these effects by modulating signaling pathways, regulating gut microbiota, influencing gene expression, and regulating epigenetic pathways. This comprehensive review summarizes the evidence regarding polyphenol intake across various life stages, exploring their effects on immune function, cognitive development, cardiovascular health, and healthy aging. These findings highlight the potential role of polyphenol supplementation in supporting lifelong health. It also emphasizes the significant impact of polyphenols on mental health issues and obesity, which have become more prevalent in modern life. The review also highlights the distinct requirements for each age group, due to changes in metabolic and cellular functions, as well as the age-specific effects of polyphenols. Recent in vitro, in vivo and clinical studies were reviewed to evaluate the biological effects of polyphenols. In the current literature, there are limited studies that directly compare the effects of polyphenols specific to different life stages and comprehensively address the results. This review aims to provide a framework to guide future research by evaluating the effects of polyphenols used in early life, adulthood, and old age.
dc.identifier.doi10.3390/ijms262211074
dc.identifier.issn1661-6596
dc.identifier.issn1422-0067
dc.identifier.issue22
dc.identifier.pmid41303557
dc.identifier.scopus2-s2.0-105023093116
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/ijms262211074
dc.identifier.urihttps://hdl.handle.net/20.500.12428/34453
dc.identifier.volume26
dc.identifier.wosWOS:001623948800001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofInternational Journal of Molecular Sciences
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20260130
dc.subjectlife stages
dc.subjectage-specific effects
dc.subjectinfancy
dc.subjectchildhood
dc.subjectadulthood
dc.subjectaging
dc.subjectsecondary metabolites
dc.titleThe Functional Role of Polyphenols Across the Human Lifespan
dc.typeReview

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