Adalimumab mitigates ovarian ischemia-reperfusion injury in rats by regulating oxidative stress, apoptosis and resolution of inflammation

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dc.authoriduzun, metehan/0000-0003-1406-5473
dc.contributor.authorBeyazit, Fatma
dc.contributor.authorBuyuk, Basak
dc.contributor.authorTurkon, Hakan
dc.contributor.authorElmas, Sait
dc.contributor.authorUzun, Metehan
dc.date.accessioned2025-01-27T20:29:35Z
dc.date.available2025-01-27T20:29:35Z
dc.date.issued2019
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractAim Ovarian torsion is a rare but an important reason of acute lower abdominal pain in women and associated with serious morbidity and mortality, if not treated promptly. The aim of this study was to evaluate the effects of an antitumor necrosis factor-alpha antibody on ovarian torsion in a rat model of ischemia-reperfusion (I/R) injury. Methods Forty female Wistar Albino rats were used in the present study. The rats were randomly divided into four groups: group I (sham), group II (I/R), group III (I/R + isotonic saline) and group IV (I/R + adalimumab). The I/R model was induced by torsion of both ovaries. Immunohistochemical staining for interleukin-1 beta (IL-1 beta), nuclear factor-kappa B (NF-kappa B), and inducible nitric oxide synthase was performed. Tissue and serum oxidative stress markers in conjunction with apoptotic index (AI) with the terminal deoxynucleotidyl transferase dUTP nick end labeling method were also calculated. Results Tissue total oxidant status, oxidative stress index and nitric oxide values were significantly decreased, and tissue total antioxidant status was found to be increased in group IV. Inflammation, vascular congestion and hemorrhagia were significantly lower in adalimumab-treated group. Serum oxidative stress markers and tissue malondialdehyde levels did not differ in study groups. The AI was significantly increased in groups 2 and 3. Adalimumab treatment significantly decreased the AI. Conclusion Adalimumab therapy in rats attenuated I/R induced ovarian injury, possibly suppressing inflammation, inhibiting oxidative stress, and altering apoptotic pathways.
dc.description.sponsorshipScientific Research Projects Coordination Unit of COMU [TSA-2017-1324]
dc.description.sponsorshipThis research was supported by The Scientific Research Projects Coordination Unit of COMU as 'Independent Research Project' (Project ID: TSA-2017-1324).
dc.identifier.doi10.1111/jog.13846
dc.identifier.endpage367
dc.identifier.issn1341-8076
dc.identifier.issn1447-0756
dc.identifier.issue2
dc.identifier.pmid30358007
dc.identifier.scopus2-s2.0-85055579656
dc.identifier.scopusqualityQ2
dc.identifier.startpage358
dc.identifier.urihttps://doi.org/10.1111/jog.13846
dc.identifier.urihttps://hdl.handle.net/20.500.12428/22990
dc.identifier.volume45
dc.identifier.wosWOS:000457558400015
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Obstetrics and Gynaecology Research
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectadalimumab
dc.subjectapoptosis
dc.subjectimmunohistochemistry
dc.subjectovarian torsion
dc.subjectoxidative stress
dc.titleAdalimumab mitigates ovarian ischemia-reperfusion injury in rats by regulating oxidative stress, apoptosis and resolution of inflammation
dc.typeArticle

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