MULTI-COMPONENT PREPARATION OF INDENO[2?,1?:5,6]PYRIDO[2,3-d]PYRIMIDINE AND REDUCTION REACTION

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dc.authoridBerber, Nurcan/0000-0002-1595-585X
dc.contributor.authorBerber, Nurcan
dc.date.accessioned2025-01-27T20:27:36Z
dc.date.available2025-01-27T20:27:36Z
dc.date.issued2020
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractPyrimidine and their derivatives play an important role in the field of pharmacological activity. Also, pyrimidine compounds containing pyrido pyrimidine structure show significant biological and pharmaceutical activities. In this study, indeno [2',1':5,6]pyrido [2,3-d]pyrimidine derivative was synthesized by the one-pot condensation. This one-pot, three-component condensation took place under mild conditions; 1,3-Indandione (indanedione) (1), 6-amino uracil (2), 4-nitro benzaldehyde (3) in DMF/Et3N at 60 degrees C. The reaction was completed after 24 h. Also, eight different methods were tried for the reduction of aryl nitro group. For the selective reduction of aryl nitro group in a good yields was used under elemental sulfur (S8), sodium sulphide (Na2S) in THF/water at 100 degrees C conditions. All coumpounds were characterized by spectroscopic techniques.
dc.description.sponsorshipSakarya University Chemistry Department
dc.description.sponsorshipThe author is grateful to Mustafa ARSLAN for all support and thanks to Sakarya University Chemistry Department.
dc.identifier.endpage513
dc.identifier.issn1018-4619
dc.identifier.issn1610-2304
dc.identifier.issue1
dc.identifier.startpage509
dc.identifier.urihttps://hdl.handle.net/20.500.12428/22731
dc.identifier.volume29
dc.identifier.wosWOS:000509426700060
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherParlar Scientific Publications (P S P)
dc.relation.ispartofFresenius Environmental Bulletin
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectOne-pot reaction
dc.subjectPyrido[2,3-d]pyrimidine
dc.subject1,3-indandione
dc.subject6-amino uracil
dc.subjectReduction reaction
dc.titleMULTI-COMPONENT PREPARATION OF INDENO[2?,1?:5,6]PYRIDO[2,3-d]PYRIMIDINE AND REDUCTION REACTION
dc.typeArticle

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