MULTI-COMPONENT PREPARATION OF INDENO[2?,1?:5,6]PYRIDO[2,3-d]PYRIMIDINE AND REDUCTION REACTION
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Tarih
2020
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Parlar Scientific Publications (P S P)
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Pyrimidine and their derivatives play an important role in the field of pharmacological activity. Also, pyrimidine compounds containing pyrido pyrimidine structure show significant biological and pharmaceutical activities. In this study, indeno [2',1':5,6]pyrido [2,3-d]pyrimidine derivative was synthesized by the one-pot condensation. This one-pot, three-component condensation took place under mild conditions; 1,3-Indandione (indanedione) (1), 6-amino uracil (2), 4-nitro benzaldehyde (3) in DMF/Et3N at 60 degrees C. The reaction was completed after 24 h. Also, eight different methods were tried for the reduction of aryl nitro group. For the selective reduction of aryl nitro group in a good yields was used under elemental sulfur (S8), sodium sulphide (Na2S) in THF/water at 100 degrees C conditions. All coumpounds were characterized by spectroscopic techniques.
Açıklama
Anahtar Kelimeler
One-pot reaction, Pyrido[2,3-d]pyrimidine, 1,3-indandione, 6-amino uracil, Reduction reaction
Kaynak
Fresenius Environmental Bulletin
WoS Q Değeri
Q4
Scopus Q Değeri
Cilt
29
Sayı
1
