Lung Adenocarcinoma and Hyperamylasemia Associated with Paraneoplastic Syndrome: A Case Report

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dc.authorid0009-0000-9172-8571
dc.contributor.authorCakici, Veli
dc.contributor.authorSuleyman, Can
dc.contributor.authorUygun, Gokhan
dc.contributor.authorYulek, Ozden
dc.date.accessioned2026-02-03T11:59:43Z
dc.date.available2026-02-03T11:59:43Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractParaneoplastic syndromes are systemic manifestations arising from tumor-associated biochemical or immunologic effects, occurring independently of direct tumor invasion. While common paraneoplastic syndromes such as hypercalcemia and hyponatremia are frequently observed in lung cancer, hyperamylasemia is a rare phenomenon, particularly associated with metastatic lung adenocarcinoma. A 67-year-old male presented with complaints of fatigue and shortness of breath. Laboratory investigations revealed elevated serum amylase (1330 U/L). The patient had no abdominal symptoms, and imaging showed no pancreatic pathology. Chest computed tomography identified a spiculated lesion in the left upper lobe of the lung, and biopsy confirmed a diagnosis of lung adenocarcinoma. Additional evaluations found no other cause for the amylase elevation, leading to a diagnosis of paraneoplastic hyperamylasemia. Following chemotherapy with carboplatin and paclitaxel, a significant reduction in serum amylase levels was observed, alongside partial tumor regression. This case highlights hyperamylasemia as a rare paraneoplastic syndrome in lung adenocarcinoma. Unexpected biochemical abnormalities in cancer patients should be evaluated as potential paraneoplastic syndromes associated with malignancy and closely monitored. In this case, the decrease in amylase levels following chemotherapy supports a paraneoplastic etiology.
dc.identifier.doi10.4274/nkmj.galenos.2025.92668
dc.identifier.endpage438
dc.identifier.issn2587-0262
dc.identifier.issue4
dc.identifier.startpage434
dc.identifier.trdizinid1365878
dc.identifier.urihttps://doi.org/10.4274/nkmj.galenos.2025.92668
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1365878
dc.identifier.urihttps://hdl.handle.net/20.500.12428/34393
dc.identifier.volume13
dc.identifier.wosWOS:001649346500001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherGalenos Publ House
dc.relation.ispartofNamik Kemal Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20260130
dc.subjectHyperamylasemia
dc.subjectlung adenocarcinoma
dc.subjectparaneoplastic syndrome
dc.titleLung Adenocarcinoma and Hyperamylasemia Associated with Paraneoplastic Syndrome: A Case Report
dc.typeArticle

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