Synthesis and investigation of antimicrobial activity of some bisbenzimidazole-derived chelating agents

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dc.authoridDulger, Basaran/0000-0002-3184-2652
dc.contributor.authorAgh-Atabay, NM
dc.contributor.authorDulger, B
dc.contributor.authorGucin, F
dc.date.accessioned2025-01-27T20:39:13Z
dc.date.available2025-01-27T20:39:13Z
dc.date.issued2003
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractThe 1,2-bis(2-benzimidazyl)-1,2-ethanediol (1), 1,4-bis(2-benzimidazyl)-1,2,3,4-butanetetraol (2), 1,3-bis(2-benzimidazyl)-2-thiapropane (3), 1,3-bis(2-benzimidazyl)-2-thia-propane-dihydrochloride (4), 1,5-bis(2-benzimidazyl)-3-thiapentane (5), and 1,5-bis(2-benzimidazyl)-3-thiapentane dihydrochloride (6) chelating ligands are synthesised and characterised by using analytical data and modem spectroscopic methods such as FT-Raman, FT-IR, H-1- and C-13-NMR spectrometers. Their antimicrobial activities are reported by comparing the in vitro activities, with those of ofloxacin, ciprofloxacin, piperacillin, ampicillin and cefazolin antibacterial agents against fresh clinical isolates. Antifungal activities are reported on Candida albicans, Candida utilis, Cryptococcus neoformans fungi, and the results are referenced with amphotericin-B, fluconazole and flucytosine antifungal agents. It has been found that all the compounds have broad spectra activity and was either more active or equipotent to those compared antibiotic and antifungal agents. (C) 2003 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
dc.identifier.doi10.1016/S0223-5234(03)00146-6
dc.identifier.endpage881
dc.identifier.issn0223-5234
dc.identifier.issn1768-3254
dc.identifier.issue10
dc.identifier.pmid14575934
dc.identifier.scopus2-s2.0-0142250757
dc.identifier.scopusqualityQ1
dc.identifier.startpage875
dc.identifier.urihttps://doi.org/10.1016/S0223-5234(03)00146-6
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23894
dc.identifier.volume38
dc.identifier.wosWOS:000186646000003
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier France-Editions Scientifiques Medicales Elsevier
dc.relation.ispartofEuropean Journal of Medicinal Chemistry
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectampicillin
dc.subjectbisbenzimidazole
dc.subjectchelating ligands
dc.subjectequipotent
dc.subjectofloxacin
dc.titleSynthesis and investigation of antimicrobial activity of some bisbenzimidazole-derived chelating agents
dc.typeArticle

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