Efficacy of Ozone and Selenium Therapy for Alcoholic Liver Injury: An Experimental Model

Basit Öğe Kaydı
dc.authoridAdali, Yasemen/0000-0002-8004-7364
dc.authoridMAKAV, MUSTAFA/0000-0003-1879-8180
dc.contributor.authorAdali, Yasemen
dc.contributor.authorEroglu, Huseyin Avni
dc.contributor.authorMakav, Mustafa
dc.contributor.authorGuvendi, Gulname Findik
dc.date.accessioned2025-01-27T20:49:42Z
dc.date.available2025-01-27T20:49:42Z
dc.date.issued2019
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground/Aim: Alcoholic liver disease is an important health problem which is reversible during early stages of liver damage, but becomes permanent with time. Nowadays, many studies focus on various agents that prevent, reduce or slow the progression of the toxic effects of alcohol. In our study, we investigated the efficiency of ozone and selenium against oxidative damage in a model of alcohol-induced liver damage. Materials and Methods: Forty-eight female Wistar Albino rats between 4 and 6 months of age and weighing 190-250 g were included in the study and were used as models of alcohol liver damage. Aspartate aminotransferase (AST), alanine aminotransferase (ALT), serum and tissue total oxidant levels, serum and tissue total antioxidant levels, and the histopathological evaluation of the liver were performed in 8 groups. Results: In the statistical analysis, it was observed that ozone and/or selenium therapies decreased the AST levels. Total oxidant and antioxidant serum levels were found to vary in serum and tissue. Ozone and/or selenium therapies decreased liver damage, according to histopathological findings. Conclusion: Through ozone and/or selenium therapies, less damage was observed histopathologically compared to the alcohol group. It is thought that the results of our study can be used in individual treatments following confirmation of liver damage in alcoholic patients.
dc.description.sponsorshipKafkas University [2016-TS 39]
dc.description.sponsorshipThis study was funded by Kafkas University (2016-TS 39). All applicable international, national, and/or institutional guidelines for the care and use of animals were followed.
dc.identifier.doi10.21873/invivo.11537
dc.identifier.endpage769
dc.identifier.issn0258-851X
dc.identifier.issn1791-7549
dc.identifier.issue3
dc.identifier.pmid31028195
dc.identifier.scopus2-s2.0-85065294177
dc.identifier.scopusqualityQ2
dc.identifier.startpage763
dc.identifier.urihttps://doi.org/10.21873/invivo.11537
dc.identifier.urihttps://hdl.handle.net/20.500.12428/25282
dc.identifier.volume33
dc.identifier.wosWOS:000465969100014
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherInt Inst Anticancer Research
dc.relation.ispartofIn Vivo
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectAlcoholic liver disease
dc.subjectozone
dc.subjectselenium
dc.subjectexperimental model
dc.titleEfficacy of Ozone and Selenium Therapy for Alcoholic Liver Injury: An Experimental Model
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu