Association Between Inherited Thrombophilia and Impaired Right Ventricular Function in Deep Vein Thrombosis Without Symptomatic Pulmonary Embolism

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dc.authoridKaratag, Ozan/0000-0002-0606-6364
dc.authoridAsgun, H. Fatih/0000-0002-8969-5886
dc.contributor.authorAsgun, Halil Fatih
dc.contributor.authorKirilmaz, Bahadir
dc.contributor.authorSaygi, Serkan
dc.contributor.authorOzturk, Okan
dc.contributor.authorSilan, Fatma
dc.contributor.authorKaratag, Ozan
dc.contributor.authorKosar, Sule
dc.date.accessioned2025-01-27T20:29:36Z
dc.date.available2025-01-27T20:29:36Z
dc.date.issued2014
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractThe aim was to evaluate the right ventricular function in patients with inherited thrombophilia and deep vein thrombosis (DVT) without pulmonary embolism. A total of 38 patients with DVT without symptomatic pulmonary embolism and 30 patients with varicose veins were enrolled. Clinical data, echocardiography, and 2 thrombophilic mutations were analyzed. Factor V Leiden (FVL) polymorphism was significantly frequent in the study group (P = .007). The difference in prothrombin G20210A polymorphism between the study and control groups was at a near-significant level (P = .058). There was statistically significant decrease in tricuspid annular plane systolic excursion values in patients with FVL and prothrombin G20210A polymorphism. Combined FVL and prothrombin G20210A polymorphisms were more closely related to the decrease in this value (P = .006). Deep vein thrombosis had no additional adverse effects on right ventricle. Impaired right ventricular systolic function occurs in FVL and prothrombin G20210A polymorphisms.
dc.identifier.doi10.1177/1076029612460426
dc.identifier.endpage277
dc.identifier.issn1076-0296
dc.identifier.issn1938-2723
dc.identifier.issue3
dc.identifier.pmid22992348
dc.identifier.scopus2-s2.0-84896863992
dc.identifier.scopusqualityQ2
dc.identifier.startpage270
dc.identifier.urihttps://doi.org/10.1177/1076029612460426
dc.identifier.urihttps://hdl.handle.net/20.500.12428/22993
dc.identifier.volume20
dc.identifier.wosWOS:000331969500006
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSage Publications Inc
dc.relation.ispartofClinical and Applied Thrombosis-Hemostasis
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectventricular dysfunction
dc.subjectright
dc.subjectvenous thromboembolism
dc.subjectblood coagulation disorders
dc.subjectinherited
dc.subjectechocardiography
dc.subjectgenetic testing
dc.titleAssociation Between Inherited Thrombophilia and Impaired Right Ventricular Function in Deep Vein Thrombosis Without Symptomatic Pulmonary Embolism
dc.typeArticle

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