Glucagon-like peptide-2 exhibits protective effect on hepatic ischemia-reperfusion injury in rats

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dc.authoridYildirim, Sule/0000-0002-1815-808X
dc.contributor.authorTopaloglu, Naci
dc.contributor.authorKucuk, Adem
dc.contributor.authorYildirim, Sule
dc.contributor.authorTekin, Mustafa
dc.contributor.authorErdem, Havva
dc.contributor.authorDeniz, Mustafa
dc.date.accessioned2025-01-27T20:44:19Z
dc.date.available2025-01-27T20:44:19Z
dc.date.issued2015
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractGlucagon-like peptide-2 (GLP-2) has potent anti-inflammatory effects and protects against experimental ischemia/reperfusion (I/R) injury in pulmonary, intestinal, and myocardial tissue. However, its protective abilities against I/R injury in the liver are unknown. We investigated the potential role of GLP-2 pretreatment on hepatic I/R injury in rats. A total of 24 rats were randomly divided into three groups (n = 8). The first group was the control group; the second group was the vehicle-treated hepatic ischemia/reperfusion (HIR, vehicle saline-treated) group; and the third group was the GLP-2 pretreated I/R (GLP2-IR) group. Each rat in the third group was intraperitoneally administered 5 mu g GLP-2 for 5 d before the procedure. A portal triad was created to induce ischemia with a vascular atraumatic clamp. After 40 min, the clamp was released to initiate hepatic reperfusion for 6 h. Blood samples and tissue specimens from the liver were obtained. Alanine aminotransferase, aspartate aminotransferase, and total bilirubin levels significantly increased in the saline-treated HIR group (P < 0.001), whereas GLP-2 pretreatment significantly decreased their levels (P < 0.01). Our data suggested that GLP-2 pretreatment may have a protective effect on liver I/R injury. However, dose-response studies are necessary to determine the most effective dose.
dc.identifier.doi10.1007/s11684-015-0403-1
dc.identifier.endpage373
dc.identifier.issn2095-0217
dc.identifier.issn2095-0225
dc.identifier.issue3
dc.identifier.pmid26290282
dc.identifier.scopus2-s2.0-84973413830
dc.identifier.scopusqualityQ1
dc.identifier.startpage368
dc.identifier.urihttps://doi.org/10.1007/s11684-015-0403-1
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24537
dc.identifier.volume9
dc.identifier.wosWOS:000368445200012
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofFrontiers of Medicine
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectischemia/reperfusion
dc.subjectliver
dc.subjectglucagon-like peptide-2
dc.subjectalanine aminotransferase
dc.titleGlucagon-like peptide-2 exhibits protective effect on hepatic ischemia-reperfusion injury in rats
dc.typeArticle

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