Bioactivity of the extracts and the isolation of lignans from the seeds of Centaurea dealbata

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dc.authoridShoeb, Mohammad/0000-0002-9486-2749
dc.authoridJaspars, Marcel/0000-0002-2426-6028
dc.contributor.authorShoeb, M.
dc.contributor.authorJaspars, M.
dc.contributor.authorMacmanus, S. M.
dc.contributor.authorThoo-Lin, P. K.
dc.contributor.authorCelik, S.
dc.contributor.authorSarker, S. D.
dc.date.accessioned2025-01-27T21:21:31Z
dc.date.available2025-01-27T21:21:31Z
dc.date.issued2006
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractCentaurea dealbata Willd. (Family: Asteraceae) belongs to the big genus Centaurea that comprises ca. 500 species. The n-hexane, dichloromethane (DCM) and methanol (MeOH) extracts of the seeds of C. dealbata have been assessed for antioxidant activity and general toxicity using, respectively, the DPPH assay, and the brine shrimp lethality assay. Both the DCM and the MeOH extract showed significant levels of antioxidant activities with an RC 50 value 6.8 x 10(-2) and 4.7 x 10(-2) mg/ mL, respectively. None of the extracts exhibited any signifi cant general toxicity (LD50 = > 1000 mg/ mL). Three major bioactive components of the MeOH extract were found to be the lignans, arctigenin, arctiin and matairesinoside. The structures of these lignans were elucidated by comprehensive spectroscopic analyses, and also by direct comparison with the respective published data. This is the first report on the occurrence of arctiin and matairesionl in C. dealbata. The distribution of these lignans within the genus Centaurea has also been presented.
dc.identifier.endpage424
dc.identifier.issn0004-2927
dc.identifier.issue4
dc.identifier.scopus2-s2.0-33947271849
dc.identifier.scopusqualityN/A
dc.identifier.startpage417
dc.identifier.urihttps://hdl.handle.net/20.500.12428/28980
dc.identifier.volume47
dc.identifier.wosWOS:000210463700006
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherUniv Granada, Editorial
dc.relation.ispartofArs Pharmaceutica
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectCentaurea dealbata
dc.subjectAsteraceae
dc.subjectBrine Shrimp Lethality Assay
dc.subjectDPPH
dc.subjectAntioxidant
dc.subjectLignan
dc.titleBioactivity of the extracts and the isolation of lignans from the seeds of Centaurea dealbata
dc.title.alternativeBioactividad de los extractos y aislamiento de los lignanos de las semillas de Centaurea dealbata
dc.typeArticle

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