The Effects of Thiopental on Cold Ischemic Injury in Renal Transplantation

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dc.authorid0000-0002-1040-3255en_US
dc.authorid0000-0003-1654-6406en_US
dc.authorscopusid56500220800en_US
dc.authorscopusid57346882300en_US
dc.authorwosidABF-4291-2021en_US
dc.authorwosidCAH-3653-2022en_US
dc.contributor.authorBüyük, Başak
dc.contributor.authorAdalı, Yasemen
dc.contributor.authorKarakoç, Ebru
dc.contributor.authorEroğlu, Hüseyin Avni
dc.contributor.authorAydeğer, Cemre
dc.date.accessioned2024-01-23T07:18:35Z
dc.date.available2024-01-23T07:18:35Z
dc.date.issued2023en_US
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
dc.description.abstractIntroduction: One of the most important factors influencing post-transplant success in kidney transplantation is preserving the viability of the organ from removal to transfer into the recipient. Aim: This study aimed to reduce the energy requirement with thiopental doses administered before organ transplantation, and to increase the organ viability by minimizing the tissue damage during the cold ischemia process. Materials and methods: Twenty female Wistar albino rats were divided into two groups: control group (group C), and thiopental group (group T). In group C, a midline incision was performed, and the renal artery was isolated under ketamine and xylazine anesthesia. A standard organ storage solution (cooled to +4°C) was used for kidney perfusion. Nephrectomy was applied, and the removed kidneys were placed into +4°C standard organ storage solution and stored at +4°C for 12 hours. Animals in group T were subjected to the procedures explained above under 85 mg/kg thiopental sodium anesthesia. After 12-hour storage, samples from the kidney tissues were fixed in 10% neutral buffered formalin. Histopathological evaluation and apoptosis detection via TUNEL method were performed. Results: Tubular necrosis was more extensive in group C compared with that in group T and this difference was statistically significant. Similarly, vacuolization was widely observed in group C, and this increase was also statistically significant. For the ‘dilatation of Bowman’s space’ parameter, a significant decrease was observed in group T compared with group C. When the apoptotic index values of both groups were examined, it was seen that they were lower in group T than those in group C. This result was statistically significant. Conclusions: These data suggest that thiopental provides protection to the kidney tissue during the cold storage process. Thiopental has been shown to decrease the number of apoptotic cells in the kidney tissue when administered to the donor before organ transplantation, increasing the organ viability.en_US
dc.identifier.citationBüyük, B., Adali, Y., Karakoç, E., Eroğlu, H. A., & Aydeğer, C. (2023). The effects of thiopental on cold ischemic injury in renal transplantation. Folia Medica, 65(1), 30–36. https://doi.org/10.3897/folmed.65.e71368en_US
dc.identifier.doi10.3897/folmed.65.e71368
dc.identifier.endpage36en_US
dc.identifier.issue1en_US
dc.identifier.pmid36855971
dc.identifier.scopus2-s2.0-85149153038
dc.identifier.startpage30en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12428/5330
dc.identifier.volume65en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorEroğlu, Hüseyin Avni
dc.institutionauthorAydeğer, Cemre
dc.language.isoen
dc.publisherMedical University of Plovdiven_US
dc.relation.ispartofFolia Medicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subjectAnimal studyen_US
dc.subjectCold ischemiaen_US
dc.subjectKidney transplantationen_US
dc.subjectThiopentalen_US
dc.titleThe Effects of Thiopental on Cold Ischemic Injury in Renal Transplantation
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dc.typeArticle

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